Table 2 Dicentric chromosome production in mouse cells
Insertion siteNormal karyotypeDicentric chromosomeAcentric chromosome>2nN optical fields
chr. 740157316100
chr. 154019231929
  • Cells with inverted loxP targets, inserted on chromosome¬†7 or chromosome¬†15, were exposed to Cre protein and scored for dicentric or acentric figures, or polyploidy (>2n), in metaphase. Chromosome-specific paints were used to recognize chromosome¬†7 or 15