Table 3 Gene-and-environment analysis on FEV1
VariantExposurenVariantExposureGxE
βPβPβP
rs58475486_T1SO2 first year6400.136.62E-06−0.050.003−0.030.658
rs57692452_C2SO2 first year6400.251.16E-06−0.050.003−0.240.091
rs111289668_G2SO2 first year6400.312.53E-08−0.050.003−0.270.079
rs73440122_C2aSO2 first year6400.317.78E-08−0.050.003−0.320.045
rs17016065_G3SO2 first year6400.118.82E-06−0.050.003−0.080.108
rs17016066_A3SO2 first year6400.118.82E-06−0.050.003−0.080.108
rs1398303_A3SO2 first year6400.103.15E-05−0.050.003−0.090.082
rs61924868_T3SO2 first year6400.103.30E-05−0.050.003−0.080.088
rs73429415_A3SO2 first year6400.091.09E-04−0.050.003−0.090.069
rs58475486_T1bSO2 past year6610.136.62E-060.050.3620.320.003
rs57692452_C2SO2 past year6610.251.16E-060.050.3620.290.100
rs111289668_G2aSO2 past year6610.312.53E-080.050.3620.410.037
rs73440122_C2SO2 past year6610.317.78E-080.050.3620.390.051
rs17016065_G3aSO2 past year6610.118.82E-060.050.3620.200.026
rs17016066_A3aSO2 past year6610.118.82E-060.050.3620.200.026
rs1398303_A3aSO2 past year6610.103.15E-050.050.3620.210.021
rs61924868_T3aSO2 past year6610.103.30E-050.050.3620.210.023
rs73429415_A3aSO2 past year6610.091.09E-040.050.3620.200.026
rs58475486_T1SO2 lifetime6610.136.62E-06−0.130.0010.260.173
rs57692452_C2SO2 lifetime6610.251.16E-06−0.130.0010.470.221
rs111289668_G2SO2 lifetime6610.312.53E-08−0.130.0010.320.444
rs73440122_C2SO2 lifetime6610.317.78E-08−0.130.0010.290.489
rs17016065_G3SO2 lifetime6610.118.82E-06−0.130.001−0.190.143
rs17016066_A3SO2 lifetime6610.118.82E-06−0.130.001−0.190.143
rs1398303_A3SO2 lifetime6610.103.15E-05−0.130.001−0.170.184
rs61924868_T3SO2 lifetime6610.103.30E-05−0.130.001−0.170.199
rs73429415_A3SO2 lifetime6610.091.09E-04−0.130.001−0.160.207
  • n, sample sizes for the gene-by-SO2 interaction analysis. Superscript 1 to 3 in the variant column, variants that are in linkage disequilibrium with the three independent signals, rs58475486, rs73429450, and rs17016065, respectively. β (P), effect sizes (P - values) from the main effects of the variants, exposure, and GxE interaction. GxE, gene–environment interaction.

  • a GxE P < 0.05.

  • b GxE P < Bonferroni P-value of 0.0056.