Table 2 Genome-wide lung function association in SAGE II children with asthma
1000 Genomes
MrsIDAltβPβnormPnormMAFALLAFRAMREURScore
1rs11835305T0.1261.93E-050.3203.69E-050.1040.0360.1190.0120.0010
2rs17015963C0.1261.93E-050.3203.69E-050.1040.0360.1200.0120.0010
3rs58475486aT0.1271.45E-050.3232.81E-050.1050.0370.1230.0120.0012^
4rs17015979T0.1271.45E-050.3232.81E-050.1050.0370.1230.0120.0010
5rs57692452C0.2451.63E-060.6541.06E-060.0330.0110.0300.0060.0012^
6rs112585732T0.2354.35E-070.6253.06E-070.0410.0160.0500.0060.0010
7rs113837356T0.2703.44E-060.7192.49E-060.0250.0080.0270.0060.0011
8rs61441836G0.2528.19E-070.6715.46E-070.0330.0100.0300.0060.0011
9rs73438172A0.2528.19E-070.6715.46E-070.0330.0100.0300.0060.0011
10rs1044043958bA0.2703.44E-060.7192.49E-060.0250
11rs73438182G0.1381.68E-040.3789.18E-050.0640.0200.0680.0060.0010
12rs73438185A0.1381.68E-040.3789.18E-050.0640.0200.0680.0060.0010
13rs73438188A0.2976.97E-080.7924.42E-080.0280.0100.0270.0060.0011
14rs73438190C0.1811.86E-050.4861.22E-050.0480.0160.0470.0060.0010
15rs73438195A0.1811.86E-050.4861.22E-050.0480.0160.0470.0060.0010
16rs111857459T0.1811.86E-050.4861.22E-050.0480.0160.0470.0060.0010
17rs144369986bT0.2851.21E-060.7569.44E-070.0250.0080.0260.0060.0010
18rs73440106G0.1811.86E-050.4861.22E-050.0480.0160.0470.0060.0010
19rs73440107A0.2976.97E-080.7924.42E-080.0280.0100.0270.0060.0011
20rs111453514C0.2976.97E-080.7924.42E-080.0280.0100.0270.0060.0011
21rs73440112T0.2976.97E-080.7924.42E-080.0280.0100.0270.0060.0011
22rs73440115G0.2976.97E-080.7924.42E-080.0280.0110.0280.0060.0011
23rs11312747bA0.1331.43E-050.3578.51E-060.1000.0360.1210.0100.0010
24rs73440120A0.2851.21E-060.7569.44E-070.0250.0080.0260.0060.0011
25rs111289668G0.2976.97E-080.7924.42E-080.0280.0100.0270.0060.0012^
26rs73440122C0.2922.08E-070.7751.55E-070.0270.0110.0300.0060.0013^
27rs73440123G0.2922.08E-070.7751.55E-070.0270.0110.0300.0060.0011
28rs17016065aG0.1123.19E-060.2962.54E-060.1770.0750.2170.0170.0091#
29rs17016066A0.1123.19E-060.2962.54E-060.1770.0750.2170.0170.0091#
30rs147400083bT0.1123.19E-060.2962.54E-060.1770
31rs866852270T0.1123.19E-060.2962.54E-060.1770
32rs141293300bC0.2922.08E-070.7751.55E-070.0270.0110.0300.0060.0011
33rs1398303A0.1041.22E-050.2741.12E-050.1860.0770.2230.0200.0091#
34rs61924868T0.1041.24E-050.2751.14E-050.1850.0780.2230.0200.0091#
35rs73440134T0.2922.08E-070.7751.55E-070.0270.0110.0300.0060.0011
36rs73429413G0.2922.08E-070.7751.55E-070.0270.0110.0300.0060.0011
37rs73429415A0.0965.13E-050.2534.84E-050.1890.0780.2250.0220.0091#
38rs112449284T0.2424.64E-060.6403.87E-060.0310.0120.0350.0070.0011
39rs111981782C0.2965.78E-080.7864.09E-080.0290.0120.0330.0060.0011
40rs150942400T0.2936.01E-080.7804.01E-080.0290.0120.0340.0060.0021
41rs147527487C0.0868.49E-050.2268.14E-050.2050.0950.2490.0160.0050
42rs111243672A0.2586.41E-070.6903.99E-070.0320.0140.0370.0070.0041
43rs73429450aA0.3021.26E-080.8019.01E-090.0310.0120.0330.0090.0021
44rs758775577C0.2172.22E-060.5741.85E-060.0410
45rs142679473bC0.2856.30E-080.7564.62E-080.0310.0120.0330.0090.0020
  • Score, priority score based on statistical and functional evidence, which is reported in Table S12. M, marker number that corresponds to those in Figure 2 and Table S12. Candidate variants were prioritized if they had a priority score of > 2 (^) or if they were expression QTL of KITLG in nasal epithelial cells (#). β (P) and βnorm (Pnorm) are the effect sizes (P-values) of the genetic associations of the alternate allele (Alt) with FEV1 and FEV1.res.rnorm, respectively. ALL/AFR/AMR/EUR, 1000 Genomes minor allele frequency from all/African/American/European populations. —, not available. MAF, minor allele frequency.

  • a The three independent signals identified in the conditional analyses.

  • b Insertions/deletions.