Table 2 C. elegans orthologs of human spliceosome component proteins
C. elegansHuman OrthologDomainsDescription
snr-2SNRPB/Sm B/B’LSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-3SNRPDl/Sm D1LSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-4SNRPD2/Sm D2LSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-1SNRPD3/Sm D3LSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-6SNRPE/Sm ELSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-5SNRPF/Sm FLSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
snr-7SNRPG/Sm GLSmSm protein (Common in U1, U2, U4 and U5 snRNPs)
gut-2LSM2/Lsm2LSmLSm protein (U6 snRNP)
lsm-3LSM3/Lsm3LSmLSm protein (U6 snRNP)
lsm-4LSM4/Lsm4LSmLSm protein (U6 snRNP)
lsm-5LSM5/Lsm5LSmLSm protein (U6 snRNP)
lsm-6LSM6/Lsm6LSmLSm protein (U6 snRNP)
lsm-7LSM7/Lsm7LSmLSm protein (U6 snRNP)
lsm-8LSM8/Lsm8LSmLSm protein (U6 snRNP)
rnp-7SNRNP70/U1-70KU1 snRNP70, RRMU1 snRNP
rnp-2SNRPA/U1ARRMU1 snRNP
snrp-3SNRPC/U1CU1 Zn fingerU1 snRNP
prp-40PRPF40A/FBP11WW, FFU1 snRNP
rbm-25RBM25/S164RRM, PWIU1 snRNP
ddx-17DDX5/p68DEAD-box helicaseU1 snRNP
tcer-1, tcer-2TCERG1/CA150WW, FFU1 snRNP
mog-2SNRPA1/U2A’Leucine-rich repeatU2 snRNP
rnp-3SNRPB2/U2B”RRMU2 snRNP
prp-21SF3A1/SF3a120SWAP, PRP21-like, UbiquitinU2 snRNP
repo-1SF3A2/SF3a66C2H2 Zn fingerU2 snRNP
prp-9SF3A3/SF3a60SF3a60 bindingU2 snRNP
sftb-1SF3B1/SF3b155Sf3b1U2 snRNP
sftb-2SF3B2/SF3b150Proline-richU2 snRNP
teg-4SF3B3/SF3b130MMS1, CPSF A subunit regionU2 snRNP
sap-49SF3B4/SF3b49RRMU2 snRNP
moa-2SF3B5/SF3b10SF3b10U2 snRNP
sftb-6SF3B6/SF3b14aRRMU2 snRNP
phf-5PHF5A/SF3b14bPHD-fingerU2 snRNP
snu-13SNU13/hSnu13L7AeU4/U6 snRNP
prp-31PRPF31/hPrp31snoRNA binding, Prp31U4/U6 snRNP
prp-3PRPF3/hPrp3PWI, PRP3U4/U6 snRNP
prp-4PRPF4/hPrp4PRP4-like, WD40 repeatU4/U6 snRNP
cyn-11PPIH/hCypHPeptidyl-prolyl cis-trans isomeraseU4/U6 snRNP
prp-8PRPF8/hPrp8PROCN, RRM, U5-snRNA binding, U6-snRNA interacting, PRP8 domain IV, MPN, PROCTU5 snRNP
snrp-200SNRNP200/hBrr2DEAD/DEAH box helicaseU5 snRNP
eftu-2EFTUD2/hSnu114GTP-binding, Elongation factor Tu, Elongation factor GU5 snRNP
snrp-40.1, snrp-40.2SNRNP40/U5-40KWD40 repeatU5 snRNP
prp-6PRPF6/hPrp6PRP1, TPRU5 snRNP
teg-1CD2BP2/hLin1GYFU5 snRNP
dib-1TXNL4A/hDib1DIM1U5 snRNP
ddx-23DDX23/hPrp28DEAD-box helicaseU5 snRNP
snrp-27SNRNP27/U4/U6.U5-27KU4/U6.U5 tri-snRNP
usp-39USP39/hSad1Ubiquitin-hydrolases Zn finger, Ubiquitin carboxyl-terminal hydrolaseU4/U6.U5 tri-snRNP
sart-1SART1/hSnu66SART-1U4/U6.U5 tri-snRNP
rbm-42RBM42RRMU4/U6.U5 tri-snRNP
uaf-1U2AF2/U2AF65RRMU2 related
uaf-2U2AF1/U2AF35CCCH Zn finger, RRMU2 related
rnp-6PUF60RRMU2 related
smr-1SMNDC1/SPF30SMNU2 related
dnj-30DNAJC8/SPF31DnaJU2 related
rbm-17RBM17/SPF45G-patch, RRMU2 related
tag-65CHERPSWAP, CTD-binding, G-patchU2 related
sap-140U2SURP/SR140RRM, SWAP, cwf21U2 related
ddx-15DHX15/PRP43DEAH-box helicaseU2 related
ddx-46DDX46DEAD-box helicaseU2 related
hel-1DDX39B/UAP56DExD/H-box helicaseTranscription and export (TREX) complex
aly-1, aly-2, aly-3ALYREF/Aly/REFRRM, FopTranscription and export (TREX) complex
thoc-1THOC1Thoc1, Death domainTranscription and export (TREX) complex
thoc-2THOC2Thoc2Transcription and export (TREX) complex
thoc-3THOC3WD40 repeat, WD40- like beta propeller repeatTranscription and export (TREX) complex
luc-7LLUC7LLUC7A complex protein
prp-39PRPF39PRP39A complex protein
tiar-1, tiar-2, tiar-3TIA1RRM, Q-richA complex protein
bub-3BUB3WD40 repeatA complex protein
-TRIR/MGC2803TRIRA complex protein
-SUGP1/SF4SWAP, G-patchA complex protein
ccar-1CCAR1/FLJ10839S1-like RNA binding, DBC1, SAPA complex protein
cdk-11.1, cdk-11.2CDK11A/CDC2L2Protein kinaseA complex protein
cus-2HTATSF1/Tat SF1RRMA complex protein
fust-1FUS/TLSRRM, RanBP Zn fingerA complex protein
rbm-5RBM5RRM, RanBP Zn finger, G-patchA complex protein
rbm-5RBM10RRM, RanBP Zn finger, G-patchA complex protein
sfa-1SF1KH, CCHC Zn fingerA complex protein
bud-13BUD13/MGC13125Bud13RES complex
pmlr-1SNIP1FHARES complex
rbmx-2RBMX2/CGI-79RRMRES complex
snu-23ZMAT2/hSnu23dsRNA-binding Zn fingerB complex protein
prp-38PRPF38A/hPrp38PRP38B complex protein
mfap-1MFAP1MFAP1B complex protein
ubl-5UBL5UbiquitinB complex protein
smu-2IK/REDRED-likeB complex protein
smu-1SMU1WD40 repeatB complex protein
multiple genesHSPB1/HSP27Hsp20B complex protein
dxbp-1KIN/HsKin17Kin17 curved DNA-bindingB complex protein
mtr-4MTREX/Skiv2L2DEAD/DEAH box helicaseB complex protein
prpf-4PRPF4B/hPrp4 kinaseProtein kinaseB complex protein
pqbp-1.1, pqbp-1.2PQBP1/NPW38WWB complex protein
wbp-11WBP11/NPW38BPWBP11B complex protein
wbp-4WBP4/FBP21U1 Zn finger, WWB complex protein
mog-4DHX16/hPrp2DEAD/DEAH box helicaseBact complex protein
let-858CWC22/KIAA1604MIF4G, MA3Bact complex protein
rnf-113RNF113ACCCH Zn finger, RING fingerBact complex protein
cyn-16CWC27/NY-CO-10Peptidyl-prolyl cis-trans isomeraseBact complex protein
cyn-4PPIL2Rtf2 RING finger, Peptidyl-prolyl cis-trans isomeraseBact complex protein
ccdc-12CCDC12cwf18Bact complex protein
cyn-10PPIL3/PPIL3bPeptidyl-prolyl cis-trans isomeraseBact complex protein
gkow-1GPKOW/hSPP2G-patch, KOWBact complex protein
prp-19PRPF19/Prp19U-box, PRP19-like, WD40 repeatPrp19 complex (nineteen complex, NTC)
cdc-5LCDC5L/CDC5Myb-like DNA-binding, Cdc5p/Cef1Prp19 complex (nineteen complex, NTC)
bcas-2BCAS2/SPF27BCAS2Prp19 complex (nineteen complex, NTC)
syf-1XAB2/hSyf1TPRPrp19 complex (nineteen complex, NTC)
syf-2SYF2/GCIP p29SYF2Prp19 complex (nineteen complex, NTC)
syf-3CRNKL1/hSyf3HAT repeatPrp19 complex (nineteen complex, NTC)
isy-1ISY1/hIsy1Isy1-likePrp19 complex (nineteen complex, NTC)
ctnb-1CTNNBL1/catenin beta like 1Catenin-beta-likePrp19 complex (nineteen complex, NTC)
hsp-1, hsp-70, F44E5.4, F44E5.5, F11F1.1HSPA8/Hsp73Hsp70Prp19 complex (nineteen complex, NTC)
rbm-22RBM22RRMNTC-related (NTR) complex
skp-1SNW1/SKIPSKIP/SNWNTC-related (NTR) complex
bud-31BUD31/G10G10NTC-related (NTR) complex
cyn-12PPIL1Peptidyl-prolyl cis-trans isomeraseNTC-related (NTR) complex
cwc-15CWC15/AD-002Cwf15/Cwc15NTC-related (NTR) complex
plrg-1PLRG1/PRL1WD40 repeatNTC-related (NTR) complex
emb-4AQR/AquariusAAANTC-related (NTR) complex
sel-13ZNF830/CCDC16C2H2 Zn fingerIntron-binding complex (IBC)
cyn-13PPIE/CypERRM, Peptidyl-prolyl cis-trans isomeraseIntron-binding complex (IBC)
cwf-19L2CWF19L2CwfJIntron-binding complex (IBC)
F33D11.10, Y65B4A.6EIF4A3/eIF4A3DEAD/DEAH box helicaseExon junction complex (EJC)
mag-1MAGOHMago nashiExon junction complex (EJC)
rnp-4RBM8A/Y14RRMExon junction complex (EJC)
casc-3CASC3/MLN51BtzExon junction complex (EJC)
mog-1DHX38/hPrp16DEAH-box helicaseStep 1 factor
yju-2YJU2/CCDC94YJU2Step 1 factor
mog-3CWC25/CCDC49CIR, CWC25Step 1 factor
sacy-1DDX41/AbstraktDEAD-box helicaseC complex protein
cacn-1CACTINCactinC complex protein
ddx-35DHX35/DDX35DEAH-box helicaseC complex protein
gpch-1GPATCH1/Q9BRR8G-patchC complex protein
cyn-15PPWD1WD40 repeat, Peptidyl-prolyl cis-trans isomeraseC complex protein
Y66D12A.8CXorf56UPF0428C complex protein
T23G11.4C9orf78HCA59C complex protein
cyn-8PPIGPeptidyl-prolyl cis-trans isomeraseC complex protein
C08H9.16FRA10AC1Fra10Ac1C complex protein
frg-1FRG1FRG1-likeC complex protein
wdr-83WDR83/MORG1WD40 repeatC complex protein
ess-2ESS2/DGCR14Es2C complex protein
R05G6.4NOSIPNOSIPC complex protein
sde-2SDE2/C1orf55Sde2C complex protein
C47E8.4FAM50A, FAM50BXAP5C complex protein
K01G5.8FAM32AFA32AC complex protein
rsr-2SRRM2/SRm300cwf21, SRRMC complex protein
prp-17CDC40/hPrp17WD40 repeatStep 2 factor
prp-18PRPF18/hPrp18PRP18Step 2 factor
mog-5DHX8/hPrp22DEAH-box helicaseStep 2 factor
sluh-7SLU7Pre-mRNA splicing Prp18-interacting factorStep 2 factor
F37A4.2PRKRIP1PRKRIP1Step 2 factor
  • This table describes C. elegans orthologs or closest homologs of human spliceosomal protein components described in Wahl and Luhrmann (2015) with some updates.