Table 1 Validation of genetic domains by mapping of functional properties in the Malpighian tubule
FunctionTubule regionReference
Fluid secretionMain segmentO’Donnell and Maddrell (1995)
Fluid reabsorptionLower tubuleO’Donnell and Maddrell (1995)
Rapid calcium excretionInitial segment of anterior tubulesK. A. Dube et al. (2000), Terhzaz et al. (2005)
Alkaline phosphataseLower tubuleSözen et al. (1997)
Ion transport by V-ATPaseMain segment principal cellsSözen et al. (1997)
Chloride shunt conductance through channelsStellate cellsCabrero et al. (2014), Feingold et al. (2019)
α-HRP binding (surrogate for neuronal isoform of Na+, K+ ATPase)Tiny cellsSözen et al. (1997)
Receptors for kinin neuropeptideStellate cellsRadford et al. (2002)
Calcium-mediated signaling by Capa neuropeptidePrincipal cellsRosay et al. (1997)