Table 1 Caspofungin MICs for screen hits
Gene locus tagGene product mutatedMIC (µg/ml)
CNAG_00375SAGA complex histone acetyltransferase (Gcn5)12.5
CNAG_02682Hypothetical protein (Msh1 homolog)0.78
CNAG_05070Sulfite reductase (NADPH) hemoprotein, β-component0.78
CNAG_06902Hypothetical protein12.5
CNAG_02236Type 2A-like serine/threonine protein phosphatase (Ppg1)0.78
CNAG_03981Palmitoyltransferase Pfa46.25
CNAG_03841Hypothetical protein12.5
CNAG_02292Copper chaperone Lys712.5
CNAG_04992Hypothetical protein12.5
CNAG_03080Fatty acid elongase12.5
CNAG_07636Chitin synthase regulator (Csr2)3.125
CNAG_02891Endoplasmic reticulum rhodanese-like protein (Rdl2)12.5
CNAG_01717Cell differentiation protein Rcd112.5
CNAG_00888Calcineurin B subunit3.125
  • MIC, minimal inhibitory concentration. SAGA: Spt3-Ada2-Gcn5 complex.