Table 1 Simulation results assuming the distribution of locus effects predicted for the Digestive disease trait
Within-locusAdditiveAdditiveh = 0.2h = 0.2h = 0
Between-locusAdditiveEpistaticAdditiveEpistaticEpistatic
Parameters
Embedded Image0.1030.1020.0680.0680.050
Embedded Image0.0000.0000.0160.0160.043
H20.1030.3320.0840.3470.370
Estimations
Embedded Image0.1040.2820.0690.2340.196
tMZ0.1040.3320.0840.3470.370
tDZ0.0520.1550.0390.1460.143
Embedded Image = 2(tMZtDZ)0.1030.3550.0910.4030.455
Embedded ImageEmbedded Image−0.0010.0730.0220.1690.259
tMZ – 2tDZ−0.0000.0220.0070.0550.085
  • Embedded Image genic narrow-sense heritability;Embedded Image genic contribution of dominance to phenotypic variance; H2, broad-sense heritability;Embedded Image GWAS estimate of heritability; tMZ, intraclass phenotypic correlation among monozygotic twins; tDZ, intraclass phenotypic correlation among dizygotic twins;Embedded Image estimate of heritability from twins. The phenotypic variance is one in all cases and no common environmental effects are assumed.