Table 4 Summary of cre-reporter expression pattern for 10 strains
PleGeneAlleleRetinaCorneaBrainSpinal cordHeart
272CLDN5tm332Positive: endothelial cellsNegativePositive: endothelial cellsPositivePositive
274CRHtm353NegativeNegativePositive: Ctx, MGM, Pir, PvHPositiveNegative
155PCP2tm347aPositive: primarily in bipolar cells, low level in amacrine and GCLNegativePositive: low level nonspecifica in the CB, Ctx, Hth, ThalNegativeNegative
155PCP2tm347bPositive: primarily in INL, low level in GCL and Müller gliaPositive: subset of endothelial, epithelial, stromaPositive: high level nonspecific in the CB, Ctx, Hipp, Hth, OB, Stri, ThalNegativePositive
265PCP2tm348aPositive: primarily in bipolar cells, low level in amacrine and GCLNegativePositive: low level nonspecific in the BS, Ctx, OBNegativeNegative
265PCP2tm348bPositive: primarily in INL, low level in GCL and Müller gliaPositive: subset of endothelial, epithelial, stromaPositive: high level nonspecific in the CB, Ctx, Hipp, Hth, OB, Stri, ThalNegativePositive
198SLC6A4tm351aPositive: widely spaced in the GCL and INLPositive: stromaPositive: low level nonspecific in the blood vesselsPositivePositive
198SLC6A4tm351bPositive: primarily in INL, low level in GCL and Müller gliaPositive: endothelial, epithelial, stromaPositive: high level nonspecific in the blood vessels, Ctx, Hipp, Hth, OB, Stri, ThalPositivePositive
264NR2E1tm346aPositive: primarily in Müller gliaNegativePositive: low level nonspecific in the blood vessels, Ctx, Hipp, Hth, OB, Stri, ThalPositivePositive
264NR2E1tm346bPositive: primarily in Müller glia, low levels in the INLPositive: endothelial, stromaPositive: high level nonspecific in the blood vessels, Ctx, Hipp, Hth, OB, Stri, ThalPositivePositive
  • tm#a (conditional) strains were crossed to a tdTomato cre reporter strain and expression induced in adult mice with tamoxifen. Tm#b (constitutive) strains were first generated by crossing tm#a strains to a flp germline-deleter strain to remove the ERT2 portion of the allele, and then the resulting tm#b was crossed to a tdTomato cre reporter strain. For both tm#a and tm#b, tdTomato expression was visualized from adult mouse tissue by epifluorescence. MaxiPromoters are described first, followed by MiniPromoters below the line. CB, cerebellum; Ctx, cortex; GCL, ganglion cell layer; Hth, hypothalamus; Hipp, hippocampus; INL, inner nuclear layer; MGM, medial geniculate; OB, olfactory bulb; Pir, piriform cortex; Ple, Pleiades promoter; PvN, paraventricular nucleus; Stri, striatum; Thal, thalamus.

  • a Neuronal and glial brain expression.