Table 4 Heritability estimates
GroupGERA h2 (95% C.I.) (N)UKB h2 (95% C.I.) (N)
Father–offspring0.546 (0.436, 0.652) (1134)0.636 (0.552, 0.716) (1820)
Father–son0.622 (0.422, 0.816) (324)0.558 (0.424, 0.688) (749)
Father–daughter0.468 (0.396, 0.654) (810)0.678 (0.57, 0.782) (1071)
Mother–offspring0.618 (0.534, 0.702) (1778)0.642 (0.588, 0.696) (4134)
Mother–son0.564 (0.402, 0.720) (514)0.652 (0.564, 0.738) (1616)
Mother–daughter0.638 (0.538, 0.736) (1264)0.65 (0.578, 0.718) (2518)
Sibling0.704 (0.612, 0.790) (1487)0.57 (0.546, 0.594) (21,650)
Sibling–male/male0.708 (0.484, 0.914) (254)0.612 (0.556, 0.666) (4202)
Sibling–female/female0.820 (0.684, 0.946) (621)0.624 (0.582, 0.664) (7659)
Sibling–male/female0.542 (0.392, 0.684) (612)0.486 (0.460, 0.534) (1820)
Array–typed PC-Relate0.211 (0.195, 0.227) (62,791)
Array–typed GCTA0.278 (0.262, 0.294) (62,791)
Array–imputed PC-Relate0.210 (0.196, 0.224) (62,791)
Array–imputed GCTA0.354 (0.331, 0.377) (62,791)
  • The estimates for parent–offspring and sibling heritabilities are twice the correlation estimates (see Materials and Methods). GERA, Genetic Epidemiology Research on Adult Health and Aging cohort; PC, principle component; UKB, UK Biobank.