Table 5 GRS in GERA and UKB ethnicity groups
P (426 SNPs)P+G+GG (457 SNPs)P+G+GGP+G+GGP+G+GGP+G+GG
GroupSexR2R2MeanSDEff.P
GERA non-Hispanic whitesF0.0320.0357.6320.2650.77210−374
GERA non-Hispanic whitesM0.0300.0326.7760.2480.61210−244
GERA LatinosF0.0390.0417.6040.2570.85610−48
GERA LatinosM0.0280.0286.7460.2390.60010−22
GERA East AsiansF0.0240.0267.3400.2430.68910−26
GERA East AsiansM0.0150.0176.5360.2120.57310−12
GERA African AmericansF0.0150.0207.6060.2290.66610−9
GERA African AmericansM0.0120.0136.6990.2120.46610−4
UKB non-Hispanic whitesF0.0270.0308.3150.2870.63910−1545
UKB non-Hispanic whitesM0.0300.0336.0170.2170.76010−1451
UKB mixed/otherF0.0330.0358.3460.2880.70010−34
UKB mixed/otherM0.0290.0325.9560.2170.74810−26
UKB East AsiansF0.0170.0208.1840.2510.57110−6
UKB East AsiansM0.0160.0145.8640.1900.59910−3
UKB African BritishF0.0130.0138.5540.2450.52410−15
UKB African BritishM0.0180.0155.8180.1790.57310−13
UKB South AsiansF0.0180.0198.2890.2690.56710−19
UKB South AsiansM0.0220.0215.9280.2070.62410−24
  • Abbreviations: P, previously-identified; G, GERA-identified; GG, GERA+GIANT-identified; R2, variance explained from GRS using GERA meta-analysis effect sizes (stratified by sex); Eff., effect; GERA, Genetic Epidemiology Research on Adult Health and Aging cohort; GIANT, Genetic Investigation of Anthropomorphic Traits consortium; UKB, UK Biobank.