Table 3 Novel loci associated with BMI (P < 5 × 10−8) in the GERA+GIANT multiethnic meta-analysis that replicate in UKB
GERAGERA+GIANTUKB
SNPChr.BPLocusaAlleleFreqInfoβPβP
rs10746571243,746,634AKT3iT/C0.3460.960.0177.7 × 10−90.0121.9 × 10−7
rs1396141241,673,745AC010739.1T/C0.6690.980.0171.2 × 10−80.0102.1 × 10−6
rs7580766242,939,351MTA3G/A0.5781.000.0154.3 × 10−80.0080.00029
rs67108712143,960,593ARHGAP15iA/G0.1461.000.0232.2 × 10−90.0201.9 × 10−11
rs4857968320,714,580U6G/A0.7491.000.0181.1 × 10−90.0141.1 × 10−8
rs14363513104,617,973ALCAMT/G0.7361.000.0161.4 × 10−80.0152.5 × 10−10
rs4833079438,654,681RP11-617D20.1iT/C0.6540.980.0162.1 × 10−100.0112.1 × 10−7
rs100199974137,048,599RP11-775H9.1T/C0.4511.000.0157.5 × 10−90.0161.5 × 10−13
rs77308985170,459,675RANBP17iA/G0.7390.980.0165.1 × 10−90.0182.2 × 10−14
rs947612673,738,661KCNQ5iG/A0.3150.980.0181.6 × 10−80.0127.1 × 10−7
rs901630698,539,519MIR2113C/T0.6171.000.0142.5 × 10−80.0192.5 × 10−19
rs65696486130,349,119L3MBTL3iC/T0.2051.000.0164.3 × 10−80.0118.7 × 10−6
rs93646876163,817,911QKIG/T0.5760.990.0161.0 × 10−90.0070.0015
rs6471932862,078,904CLVS1T/A0.1080.950.0241.6 × 10−80.0176.5 × 10−8
rs1235278596,956,850KDM4CiA/C0.2820.990.0185 × 10−110.0099.4 × 10−5
rs1180675561063,136,165TMEM26C/T0.9660.890.0445.6 × 10−90.0301.8 × 10−6
rs107427521145,438,374RP11-430H10.4C/T0.6280.990.0153.9 × 10−90.0121.8 × 10−8
rs111704681239,430,048RP11-554L12.1A/C0.7870.990.0171.2 × 10−80.0114.6 × 10−6
rs18198441268,205,604RP11-43N5.1A/G0.1810.990.0194.4 × 10−90.0144.1 × 10−7
rs23727161299,573,426ANKS1BiC/T0.1980.990.0173.1 × 10−80.0151.4 × 10−8
rs95959081333,184,288PDS5BiT/C0.6500.980.0166.5 × 10−100.0171.1 × 10−14
rs95635761358,670,147RN5S30C/T0.8161.000.0229.7 × 10−120.0247.1 × 10−18
rs716119414101,529,005MIR377A/G0.3410.900.0191.5 × 10−90.0181.3 × 10−14
rs128998501566,051,299DENND4AiC/T0.7881.000.0204.0 × 10−80.0110.00012
rs110818181831,251,088ASXL3iA/G0.4680.990.0166.4 × 10−90.0121.5 × 10−8
rs61420962032,686,658EIF2S2iA/G0.5231.000.0161.1 × 10−80.0132.3 × 10−9
rs177597962222,190,163MAPK1iA/C0.1331.000.0202.5 × 10−80.0100.00067
  • Genomic context within gene, or surrounding genes, are given. Replication test is given by the UKB meta-analysis. GERA+GIANT P-values are based on the multiethnic meta-analysis of GWAS (GERA: 81,278 non-Hispanic whites, 8322 Hispanic/Latinos, 7290 East Asians, 3069 African Americans, and 459 South Asians; GIANT: 234,069 non-Hispanic whites) from the GERA sex-combined data set; GIANT+UKB P-values are based on the multiethnic meta-analysis of the European ancestry GIANT cohort members and the UKB (431,743 non-Hispanic whites, 7620 mixed/other, 9275 South Asians, 1822 East Asians, and 8261 African British). GERA, Genetic Epidemiology Research on Adult Health and Aging cohort; GIANT, Genetic Investigation of Anthropomorphic Traits consortium; UKB, UK Biobank; Chr., chromosome; Bp, base pair (based on University of California Santa Cruz Genome Browser Assembly February 2009: GRCh37/hg19); Freq., frequency; Info., information; β, β coefficient.

  • a Genomic context: i, intron; no label is intergenic.