Table 3 Identification and characterization of Sti1-dependent mutations of Hsp90
MutationHow identifiedSti1 dependence demonstrated
Hsc82Hsp82
E199KSti1-dependent screen (this study)This study
G309SG313STemperature-sensitive screen (Flom et al. 2007)Flom et al. (2007)
Y344CSti1-dependent screen (this study)This study
I388NSti1-dependent screen (this study)This study
V391EDefect in Aha1 interaction (Retzlaff et al. 2010)This study
K399CDefect in Hsp70 interaction (Kravats et al. 2018)Kravats et al. (2018)
S481YTemperature-sensitive screen (Flom et al. 2007)Flom et al. (2007)
S485TSti1-dependent screen (this study)This study
L487SL491STemperature-sensitive screen (Flom et al. 2007)Flom et al. (2007)
E507QDefect in client interaction (Genest et al. 2013)This study
W585TDefect in client interaction (Genest et al. 2013)This study
M589ATemperature-sensitive screen (Flom et al. 2007)Flom et al. (2007)
M593TSti1-dependent screen (this study)This study
G655DSti1-dependent screen (this study)This study