Table 1 The DHSs with rapid evolution in human lineage compared to all other species
StartEndTarget gene from HI-C dataTF from ChIP-seq dataHuman-gain TF motif from FIMO and ChIP-seq dataeQTLSNP located at the TF motif
3006312030063775ABCF1,TRIM15,TRIM31FOSL2, FOS, JUND, RXRA, HNF4G, HNF4A, FOXA2, FOXA, MAX, MYC, USF1, USF2FIMO: SOX9;rs7761563/HCG9, rs7741418/HCG9rs7741418/USF, MYC
ChIP-seq: USF, MYC/MAXrs7765810/HCG9rs7765810/HNF4
rs576022961/FOXA
3009480030095910HLA-W, HCG4P3, TRIM40, TRIM39, DAQB-335A13.8, HCG4P8, HLA-G, HLA-UnoneFIMO: GATA1, HIC1, OLF1rs9261447/TRIM31, TRIM40none
3009754530100218TRIM15, HLA-E, HLA-A, HLA-F, TRIM26, TRIM26P1, TRIM31, TRIM39, TRIM40STAT1, MAFK, CTCF, CTCFL, PBX3FIMO: ER(ESR1, ESR2);rs9261450/TRIM31, TRIM40,STAT1rs9261450/STAT1
ChIP-seq: STAT1, MAFK, UA2rs984319427/UA2
rs114565826/UA2
3010296830104164HLA-PHNF4A, FOXA1, FOXA2, STAT1nonenonenone
3012898030129442noneGATA1nonenonenone
3014044230140975TRIM26P1nonenonenonenone
3056814030569070HCG22, NRMnoneFIMO: SP3(3′UTR)nonenone
3057368030574016TRIM39, TRIM39-RPP21, HLA-E,nonenonenonenone
3280837832808930HLA-DRB6, HLA-DMB, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DQB2RUNX3, EBF1FIMO: GLI3(3′UTR)noners112080182/RUNX1
rs554021812/EBF1
3366420933665085noneEBF1, PBX3, ZNF263, FOS, JUNFIMO: BEN(3′UTR)nonenone
3369367033695328noneZNF263FIMO: P53_DECAMER, BENnonenone
3376092633761554noneRESTnonenoners114889417/REST
rs779529174/REST
rs758088611/REST