Table 2 Main results of “context-independent” modelsa and the present model (FGM) when stress only affects Embedded Image (only shifts the optimum position in our model)
Context-Independent ModelFGM Rescue Model
Impact of decay rate Embedded ImageEmbedded Image Embedded ImageEmbedded Image (1)
Impact of mutational input Embedded ImageEmbedded ImageEmbedded Image
“Characteristic decay rate” (Embedded Image) for DN rescue vs. Embedded ImageEmbedded ImageEmbedded Image
Relative contribution of standing variance to ERIncreases with Embedded Image Embedded Image∼ Stable with Embedded Image Embedded Image
  • When the dependence to the parameters is given for the overall rate of rescueEmbedded Image it applies to both the rate of rescue from de novo mutations Embedded Image and from pre-existing variance Embedded Image (1) derived from the approximate expression Embedded Image

  • a Orr and Unckless 2008, 2014; Martin et al. 2013