Table 1 Trait-associated variants with Bonferroni-corrected significant evidence of being under polygenic adaptation in the 1000 Genomes data, using the Embedded Image statistic: Embedded Image where n is the number of GWAS tested, assuming a Embedded Image distribution
GraphTraitPEmbedded ImageEmbedded Image
Seven-leaf treeHeight**Embedded ImageEmbedded ImageEmbedded Image
Educational attainment**Embedded ImageEmbedded ImageEmbedded Image
Unibrow*Embedded Image0.012Embedded Image
Male-pattern baldness0.0006790.1770.007
Five-leaf graphHeight**Embedded ImageEmbedded ImageEmbedded Image
Educational attainment**Embedded ImageEmbedded ImageEmbedded Image
Schizophrenia*0.0006080.010.007
UnibrowEmbedded Image0.056Embedded Image
Male-pattern baldness0.0005620.2130.003
  • We also computed P-values from 1000 samples in which we randomly switched the sign of effect size estimates, to simulate neutrality while preserving the genetic architecture of the traits (Embedded Image). Additionally, we computed P-values from an empirical null distribution produced using 1000 samples, each containing SNPs that were frequency-matched to the trait-associated SNPs, using their allele frequency in CEU, to account for each GWAS’s ascertainment scheme (Embedded Image).

  • * Trait-associated variants for which Embedded Image

  • ** Trait-associated variants for which Embedded Image.