Table 4 Gompertz parameters for genetically altered mouse strains with shortened life span from a regression line calculated by ln(Rm(t)) = ln(R0) + αt (see Methods)
Gene or proteinTypeStrainαα SEln(R0)r2MRDT (yr)
Aag, Atm, MgmtaWTC57BL/63.810.82−8.830.780.18
Aag –/–a2.201.04−5.380.530.31
Mgmt –/–3.080.50−7.650.860.23
Atm –/–a2.211.03−2.390.480.31
Aag –/– Mgmt –/–a1.660.41−4.380.650.42
ATRWTN/AN/AN/AN/AN/AN/A
ATRs/s6.461.33−3.380.860.11
Brca1WT129O1a × C57BL/6J4.590.36−10.010.980.15
+/− (female)3.960.48−8.060.970.17
Bub3 + Rae1WT129Sv/E × C57BL/61.540.34−4.860.910.45
+/−, +/−1.160.49−3.720.610.60
Casp2aWTC57BL/61.460.31−5.390.790.47
−/−3.200.44−9.440.910.22
Cd42 GAPaWTC57BL/6+/− 129/Sv3.391.11−8.160.610.20
−/−1.241.44−2.890.870.56
Cisd2aWTC57BL/6 (B6)3.420.81−8.370.640.20
Cisd2−/−1.020.36−2.100.660.68
Cisd2aWT maleC57BL/67.672.86−17.790.710.09
+/– malea4.061.26−9.680.680.17
–/– male5.561.11−11.060.860.12
WT female6.622.27−14.430.900.10
+/– femalea2.500.49−5.690.810.28
–/– femalea2.440.40−5.160.840.28
DNA pol βWTC57BL/63.060.59−9.420.790.23
+/–3.110.65−9.110.820.22
Fgf-23−/−Sv129J6.48N/A−1.760.410.11
Fn1aWTC57BL/61.490.48−5.220.620.46
Fn1EDA −/−2.730.56−6.010.820.25
Htr1baWT4.950.83−13.740.900.14
−/−4.060.46−9.560.940.17
HtrA2/Omimnd2/mnd2;TgC57BL/6JN/AN/AN/AN/AN/A
mnd2/+;Tg5.381.69−7.160.840.13
IKK-βaMBH-GFPC57BL/64.781.09−12.430.760.15
N/Ikbkbl/l6.030.84−14.370.900.12
junDaWTN/A2.670.77−5.850.750.26
JunD−/−N/A3.890.57−7.470.900.18
Msh2WT129S/SvEvTacN/AN/AN/AN/AN/A
−/−1.69N/A−2.690.260.41
Pasg−/−129/SvJ/C57BL/6J64.15N/A−2.550.750.01
PpargaWT4.430.53−11.020.930.16
Pparg2−/−2.590.29−6.930.920.27
Sirt7WTC57Bl/6 × 129SvN/AN/AN/AN/AN/A
−/−2.16−2.010.710.32
Socs2aWTC57BL/6J × FVB2.140.40−5.160.850.32
hg/hg1.430.33−2.690.730.48
Stub1aWTC57BL/6 × 129SvEv0.800.40−3.780.440.87
−/−1.310.44−2.460.590.53
Trp63aWTK5CrePR12.90N/A−7.470.860.24
+/−1.75N/A−3.720.830.40
Xrcc5aWT2.680.35−5.840.940.26
Ku86 −/−1.630.38−2.340.700.43
Xrcc6aWT1.920.30−4.980.890.36
Ku70 −/−1.390.44−1.490.830.50
  • α, age-specific exponential coefficient; ln(R0), nonexponential factor in mortality; MRDT, mortality rate doubling time as in Embedded Image yr, year; WT, wild-type; N/A, not applicable; Tg, transgenic.

  • a Indicates genes for which the changes in MRDT were statistically significant (P < 0.05).