Table 3 Gompertz parameters for genetically altered mouse strains with extended life span from a regression line calculated by ln(Rm(t)) = ln(R0) + αt (see Methods)
Gene or proteinTypeStrainαα SEln(R0)r2MRDT (yr)
Adcy5WT129/SvJ-C57BL/63.870.94−9.610.710.18
−/−5.950.34−17.200.970.12
Agrt1aWTC57BL/6 × 129/SvEv5.201.21−11.150.860.13
−/−3.951.30−10.810.700.18
Arf/p53WTC57BL/6J2.880.32−7.590.940.24
s-Arf/p532.800.44−8.050.860.25
Atg5WTC57BL/67.305.48−14.400.470.10
Atg5-Tg8.921.31−21.540.820.08
BubR1aWTC57BL/6-SV1291.620.16−5.420.920.43
mBubR1-Tg2.610.097−7.480.930.27
CatWT40332.300.18−6.400.810.30
MCATC57BL/6J3.000.59−8.800.680.23
WT44032.000.21−5.930.620.35
MCAT2.200.20−7.410.780.32
Cisd2aWT maleC57BL/67.672.86−17.790.710.09
Cisd2-Tg male6.961.84−19.390.830.10
WT female6.622.27−14.430.900.10
Cisd2-Tg female2.400.59−7.100.740.29
Clk-1WT129Sv/J3.090.64−6.050.890.22
+/−2.490.92−5.950.640.28
Dgat1aWTC57BL/6J1.920.53−5.120.660.36
−/−3.560.20−9.630.990.19
Esp8WTC57BL/61.500.22−3.700.730.46
−/−1.980.18−5.150.810.35
FGF21aWTC57Bl/6J1.820.35−5.660.820.38
FGF21-Tg2.040.40−7.890.870.34
GhrhaWTC57BL/6 × 129SV1.310.18−3.550.900.53
KO1.530.17−5.120.940.45
Gpx4aWTC57BL/63.111.08−9.180.730.22
+/–5.430.72−15.770.950.13
hMTH1aWTC57BL/63.500.65−8.780.810.20
hMTH1-Tg2.290.47−6.910.720.30
HttWT129/Sv-2.301.01−6.030.560.30
ΔQ /ΔQ1.800.51−5.190.810.39
Igf1WTFVB1.060.26−3.020.740.65
Igf11.350.25−4.430.770.51
IκB-αMBH-GFPC57BL/64.150.74−10.750.650.17
MBH-DN IB-α4.430.76−12.860.620.16
Irs1WT (female)C57BL/62.180.26−5.000.800.32
−/− (female)1.940.31−6.450.710.36
Irs2aWTC57BL/6J2.990.13−7.290.870.23
Brain-specific +/−6.370.33−17.730.850.11
MifWTC57BL/6J × 129/SvJ2.450.40−6.080.840.28
−/−1.900.31−6.020.820.37
mTORaWT129 × C57BL/61.470.45−4.460.680.47
KO2.410.15−6.940.980.29
MycWT femaleC57BL/62.190.55−5.880.760.32
+/– female3.191.05−9.640.700.22
WT male2.530.21−7.060.960.27
+/– male2.550.36−7.750.900.27
PAPP-AWTC57BL6 × 129SV/E2.330.35−5.280.710.30
−/−2.670.32−7.390.800.26
PtenWTC57BL/6 × CBA2.330.14−5.830.970.30
Pten-Tg2.520.24−7.070.950.27
RpS6K1WTC57BL/61.810.069−4.640.930.38
−/−1.730.056−5.300.910.40
RIIβWTC57BL/6 (males)3.000.31−7.680.850.23
RIIB −/−3.550.34−10.090.880.20
Sirt1aWTC57BL/62.450.49−7.200.810.28
Brain-specific Tg3.630.63−10.710.830.19
Slc13a1aWT (male)C57BL/6J × 129/SV1.790.37−4.340.830.39
Nas1 −/− (male)1.700.47−5.020.720.41
WT (female)0.870.13−2.950.860.80
Nas1 −/− (female)1.690.29−4.310.850.41
Surf1aWTBDF1 × cre2.190.39−4.810.860.32
−/−3.410.47−7.820.960.20
TgTertaSp53C57BL/6 × DBA/22.740.33−6.510.950.25
Sp53a /TgTert3.340.41−8.140.940.21
Sp53/Sp16/SArf1.470.58−4.860.520.47
Sp53/Sp16/SArf/TgTert2.080.65−7.240.770.33
  • α, age-specific exponential coefficient; ln(R0), nonexponential factor in mortality; MRDT, mortality rate doubling time as in Embedded Image yr, year; WT, wild-type; Tg, transgenic; KO, knockout.

  • a Indicates genes for which the changes in MRDT were statistically significant (P < 0.05).