Table 1 Mortality and life span statistics of genetically altered mouse strains with extended life span
Gene or proteinTypeStrainGendernt50 (yr)tmax (yr)Reference
Adcy5WT129/SvJ-C57BL/6M & F252.082.75Yan et al. (2007)
−/−M & F132.753.08
Agrt1aWTC57BL/6 × 129/SvEvM102.082.41Benigni et al. (2009)
−/−M202.633.00
Arf/p53WTC57BL/6J1112.313.30Matheu et al. (2007)
s-Arf/p53252.633.03
Atg5WTC57BL/6651.932.14Pyo et al. (2013)
Atg5-Tg702.262.52
BubR1WTC57BL/6-SV129M:30601.722.9Baker et al. (2013)
F: 30
mBubR1-TgM:29572.023.42
F:28
CatWT4033M & F442.162.83Schriner et al. (2005)
MCAT4033M & F202.583.10
WT4403M & F582.183.06
MCAT4403M & F422.603.33
Cisd2WT (M)C57BL/6M402.252.90Wu et al. (2012)
Cisd2-Tg (M)M342.693.07
WT (F)F252.272.50
Cisd2-Tg (F)F212.743.25
Clk-1WT129Sv/JF122.012.30Liu et al. (2005)
+/−F102.342.54
Dgat1WTC57BL/6JF302.042.81Streeper et al. (2012)
−/−F302.583.05
Esp8WTC57BL/6M:13291.742.72Tocchetti et al. (2010)
F:16
−/−M:20392.163.00
F:19
FGF21WTC57Bl/6JM:32672.343.56Zhang et al. (2012)
F:35
FGF21-TgM:37773.18NR (> 3.65)
F:40
GhrhWTC57BL/6M:561081.753.20Sun et al. (2013)
× 129SVF:52
KOM:39972.553.58
F:58
Gpx4WTC57BL/6502.633.34Ran et al. (2007)
+/–502.833.17
hMTH1WTC57BL/6M422.172.64De Luca et al. (2013)
hMTH1-TgM342.513.21
HttWT129/Sv-M:1152.342.93Zheng et al. (2010)
F:14
ΔQ/ΔQM:2152.763.43
F:13
Igf1WTFVBM391.973.17Li and Ren (2007)
Igf1-TgM382.433.42
IκB-αMBH-GFPC57BL/6232.412.91Zhang et al. (2013)
MBH-IκB-α312.643.09
Irs1WT (F)C57BL/6F212.022.86Selman et al. (2009)
−/− (F)F142.663.61
Irs2WTC57BL/6JM:21932.362.86Taguchi et al. (2007)
F:30
Brain-specific +/−M:27652.813.34
F:60
MifWTC57BL/6J × 129/SvJF242.012.70Harper et al. (2010)
−/−F392.453.51
mTORWT129 × C57BL/6M & F342.133.14Wu et al. (2013)
KOM & F432.513.14
MycWT (F)C57BL/6F372.232.86Hofmann et al. (2015)
+/− (F)F392.683.58
WT (M)M422.413.00
+/− (M)M422.663.26
PAPP-AWTC57BL6 × 129SV/EM & F211.842.44Conover and Bale (2007)
−/−M & F202.643.11
PtenWTC57BL/6M:491122.172.92Ortega-Molina et al. (2012)
× CBAF:63
Pten-TgM:32642.443.21
F:32
RpS6K1WTC57BL/6M:26492.233.00Selman et al. (2009)
F:23
−/−M:19482.643.40
F:29
RIIβWTC57BL/6 (males)M202.422.79Enns et al. (2009)
RIIB −/−M202.753.07
Sirt1WTC57BL/6M & F312.303.01Satoh et al. (2013)
Brain-specific TgM & F342.563.11
Slc13a1WT (M)C57BL/6J × 129/SVM211.932.60Markovich et al. (2011)
Nas1 −/− (M)M252.543.30
WT (F)F341.682.50
Nas1 −/− (F)F382.062.90
Surf1WTBDF1 × creM:23481.78NRDell’agnello et al. (2007)
F:25
−/−M:21432.172.48
F:22
TertSp53C57BL/6 × DBA/2M & F682.133.09Tomás-Loba et al. (2008)
Sp53/TgTertM & F562.363.22
Sp53/Sp16/SArfM & F392.383.18
Sp53/Sp16/SArf/TgTertM & F272.383.26
  • t50, median life span; tmax, maximum life span; yr, year; WT, wild-type; M, male; F, female; Tg, transgenic; NR, not reported; KO, knockout.