Table 2 Mortality and life span statistics of genetically altered mouse strains with shortened life span
Gene or proteinTypeStrainGendernt50 (yr)tmax (yr)Reference
Aag, Atm, MgmtWTC57BL/6M & F372.032.87Meira et al. (2014)
Aag –/–M & F291.802.50
Mgmt –/–M & F501.922.77
Atm –/–M & F190.561.37
Aag –/– Mgmt –/–M & F311.672.71
ATRWTM & F20NRNRMurga et al. (2009)
ATRs/sM & F270.420.65
Brca1WT129O1a × C57BL/6JF322.152.56Jeng et al. (2007)
+/−F261.942.53
Bub3 + Rae1WT129Sv/E × C57BL/6N/A702.08NRBaker et al. (2006)
+/−, +/−N/A1001.84NR
Casp2WTC57BL/6N/A642.623.51Zhang et al. (2007)
−/−N/A642.623.25
Cdc42WTC57BL/6+/− 129/SvM & F162.282.49Wang et al. (2007)
−/−M & F211.092.50
Cisd2WTC57BL/6 (B6)M & F492.092.53Chen et al. (2009)
Cisd2−/−M & F161.282.15
Cisd2WTC57BL/6M402.252.90Wu et al. (2012)
+/–M512.052.57
–/–M271.762.32
WTF252.272.50
+/–F471.922.50
–/–F491.832.94
DNA pol βWTC57BL/6M602.543.19Cabelof et al. (2006)
+/–M672.543.19
Fgf-23−/−Sv129JM & F150.120.26Razzaque et al. (2006)
Fn1WTC57BL/6M392.43NRMuro et al. (2003)
Fn1EDA −/−M531.93NR
HtrA2/Omimnd2/+;TgC57BL/6JM & F23N/AN/AKang et al. (2013)
mnd2/mnd2;TgM & F211.281.50
Htr1bWTN/A212.583.14Sibille et al. (2007)
−/−N/A242.052.75
IKK-βMBH-GFPC57BL/6M232.412.91Zhang et al. (2013)
N/Ikbkbl/lM242.232.56
junDWTN/AM & F351.912.41Laurent et al. (2008)
JunD−/−N/AM & F351.662.17
Msh2WT129S/SvEvTacM & F51NRNRWei et al. (2003)
−/−M & F320.580.92
Pasg−/−129/SvJ/C57BL/6JN/A630.010.07Sun et al. (2004)
PpargWTF252.352.68Argmann et al. (2009)
Pparg2−/−F262.142.62
Sirt7WTC57Bl/6 × 129SvM98NRNRVakhrusheva et al. (2008)
−/−M320.741.60
Socs2WTC57BL/6J × FVBM & F1232.103.00Casellas and Medrano (2008)
hg/hgM & F1461.332.59
Stub1WTC57BL/6 × 129SvEvM:82822.08NRMin et al. (2008)
F:84
−/−M:581280.89NR
F:45
Trp63WTK5CrePR1NR742.233.00Keyes et al. (2005)
+/−NR1041.742.25
Xrcc5WTNR472.042.40Vogel et al. (1999)
Ku86 −/−NR890.791.75
Xrcc6WTM & F272.172.80Li et al. (2007)
Ku70 −/−M & F430.691.45
  • t50, median life span; tmax, maximum life span; yr, year; WT, wild-type; M, male; F, female; Tg, transgenic; NR, not reported;