Table 1 Representative zebrafish drug discovery studies
ConditionRepresentative studies
ToxicityOtotoxicityOwens et al. (2008)
CardiotoxicityMilan et al. (2003)
Structural defects/deathPadilla et al. (2012), Sandoval et al. (2013)
Organophosphate toxicityJin et al. (2013)
Cyanide toxicityNath et al. (2013)
Nanoparticle toxicityChakraborty et al. (2016)
DevelopmentalMitotic defectsStern et al. (2005)
Tissue regenerationMathew et al. (2007)
Hair regenerationNamdaran et al. (2012), Thomas et al. (2015)
EmbryogenesisYu et al. (2008), Colanesi et al. (2012)
DorsalizationHao et al. (2013)
Ectopic tailGebruers et al. (2013)
HearingOu et al. (2010)
CraniofacialKong et al. (2014)
BehavioralSleepRihel et al. (2010)
Light stimuliKokel et al. (2010)
Learning, acoustic startleWolman et al. (2011)
Motor activityKokel et al. (2013)
AnxietyCollier (2017)
CardiovascularAortic coarctationPeterson et al. (2004)
Long QT syndromePeal et al. (2011)
Hypertrophic cardiomyopathyBecker et al. (2012), Becker and Rinkwitz (2012)
CardiomyopathyLiu and Leach (2011), Asimaki et al. (2014)
VascularAngiogenesisTran et al. (2007), Wang et al. (2010), Vazão et al. (2017)
RespiratoryTuberculosisOrdas et al. (2015)
HyperventilationRahbar et al. (2016)
NeurologicalNotochord defectsIshizaki et al. (2010)
HematopoiesisHematopoiesisNorth et al. (2007)
B-cell differentiationRovira et al. (2011)
B-cell proliferationTsuji et al. (2014)
Leukocyte migrationLiu et al. (2013)
AnemiaFernández-Murray et al. (2016)
Gastrointestinal and MetabolismLipid absorptionClifton et al. (2010)
Glucose homeostasisNath et al. (2015)
Intestinal motilityde Alvarenga et al. (2017)
Inflammatory bowel diseaseHanyang et al. (2017)
CancerLeukemiaYeh et al. (2009), Ridges et al. (2012), Gutierrez et al. (2014), Deveau et al. (2017), Hanyang et al. (2017)
MelanomaWhite et al. (2011)
Wnt-activated cancersNishiya et al. (2014)
RenalPolycystic kidney diseaseCao et al. (2009)
NephroprotectantSharma et al. (2014)