Table 4 Annotation of 12 novel phenotype pairs
Phenotype pairTotal genes (levels)aEpidemiological evidenceLDSC evidencebCatalog evidencesc
ALZ-HDL3 (Gene)Casserly and Topol (2004)F; across clusters6*; TOMM40, APOC1
AN-CHD1 (Gene)Casiero and Frishman (2006)F; across clusters0; NA
AN-LDL1 (Gene)Weinbrenner et al. (2004)F; across clusters0; NA
AM-CD18 (Gene)Ballinger et al. (2003)F; across clusters1; 0
AM-UC24 (Gene)Ballinger et al. (2003)F; across clusters2; 0
BMI-SCZ6 (Gene)Zammit et al. (2007)T; across clusters2; 0
BMI-TG11 (Gene)Locke et al. (2015)T; within cluster1; 0
CD-FG5 (Gene)Bregenzer et al. (2006)F; across clusters1; 0
CD-LDL8 (Gene)Agouridis et al. (2011)F; across clusters1; 0
CD-TG8 (Gene-set)Agouridis et al. (2011)F; across clusters2; 0
HH-SCZ8 (Gene)Zammit et al. (2007)F; across clusters9*; 0
T2D-TG2 (Gene)Locke et al. (2015)T; within cluster1; 0
  • a Gene-sets was considered by counting genes in gene-sets with GATES P < 0.05; cells with gene-set sharing were underscored.

  • b F, for near-zero genetic correlation; T, for nonzero genetic correlation; within clusters or cross clusters was given in Figure 2.

  • c Overlapping genes were counted from GWAS Catalog reported genes for each phenotype pair, with “*” showing significance after multiple testing; only hits replicated at both phenotypes in Catalog were given. NA, not applicable.