Table 1 Isolation of mutations that suppress the constitutive dauer-entry phenotype induced by phosphorylation of eIF2α in two sensory neurons in the daf-28(sa191) mutant
GeneMammalian orthologNumber of recovered allelesSuppressor genotypeMolecular alterationFraction of dauers (mean ± SD)Total number of animals
daf-28β-type insulin2daf-28(sa191)aN/A0.99 ± 0.02465
daf-28(sa191qd330)DAF-28(M1I R37C)0228
daf-28(sa191qd331)DAF-28(R37C Q81X)0214
erp-44.1 (c30h7.2)ERp443erp-44.1(qd317);daf-28(sa191)Splice site mutationb0.005 ± 0.012433
erp-44.1(qd329);daf-28(sa191)ERP-44.1(W4X)0.026 ± 0.031347
pek-1PERK18daf-28(sa191);pek-1(qd337)PEK-1(R649X)0231
daf-28(sa191);pek-1(qd342)PEK-1(R519X)0210
eif-2a (y37e3.10)eIF2α1eif-2a(qd338);daf-28(sa191)EIF-2a(S49F)0131
eif-2Ba (zk1098.4)eIF2Bα11eif-2Ba(qd333);daf-28(sa191)EIF-2Ba(E28K)0.002 ± 0.003580
eif-2Ba(qd334);daf-28(sa191)EIF-2Ba(T41I)0.01 ± 0.01472
eif-2Ba(qd335);daf-28(sa191)EIF-2Ba(M1a)b0.06 ± 0.01318
eif-2c (y39g10ar.8)eIF2γ1eif-2c(qd336);daf-28(sa191)EIF-2c(S443L)0119
  • a Starting strain.

  • b See further descriptions of molecular identity in Table S1 in File S1.