Table 3 We infer more nearly neutral (|s| < 10−5) and fewer strongly deleterious (|s| ≥ 10−2) new mutations than previous studies
Data setμ, LNS/LSBest fit DFE0 ≤ |s| < 10−510−5 ≤ |s| < 10−410−4 ≤ |s| < 10−310−3 ≤ |s| < 10−210−2 ≤ |s|
Boyko et al. (2008) (AAa)1.8 × 10−8, 2.5bGamma0.1830.0960.1470.2190.355
1000 Genomes1.8 × 10−8, 2.5bGamma0.217 (0.212–0.223)0.112 (0.111–0.113)0.169 (0.165–0.172)0.243 (0.235–0.249)0.259 (0.252–0.266)
ESPGamma0.229 (0.223–0.234)0.105 (0.104–0.106)0.152 (0.150–0.155)0.216 (0.212–0.221)0.298 (0.294–0.302)
LuCampDiscrete0.278 (0.221–0.303)0.027 (0.001–0.110)0.211 (0.167–0.234)0.352 (0.330–0.373)0.132 (0.124–0.142)
1000 Genomes1.5 × 10−8, 2.31Gamma0.237 (0.231–0.243)0.127 (0.125–0.128)0.192 (0.188–0.197)0.266 (0.259–0.272)0.178 (0.171–0.186)
ESPNeu+gamma0.263 (0.250–0.277)0.104 (0.091–0.114)0.167 (0.160–0.173)0.249 (0.241–0.259)0.217 (0.211–0.221)
LuCampNeu+gamma0.242 (0.223–0.260)0.091 (0.072–0.107)0.194 (0.183–0.203)0.332 (0.313–0.352)0.141 (0.129–0.152)
  • Results in comparison with data from Boyko et al. (2008). C.I.’s were constructed by Poisson resampling the nonsynonymous SFS and fitting a DFE 200 times. See Table S5 in File S1 for additional information. Neu, neutral.

  • a African-American.

  • b The results presented with the assumptions LNS/LS = 2.5 and μ = 1.8 × 10−8 match the mutation rate assumptions of Boyko et al. (2008).