Table 4 Multivariable robust Cox model results for the 34 top AMD risk variants on progression to late AMD
VariantChrMajor/minor allelelocus nameaEffect on progression (AREDS)Effect on progression (AREDS2)
HRP ValueHRP Value
rs109221091C/ACFH0.697.2 × 10−91.090.19
rs118847702C/TCOL4A31.020.690.861.2 × 10−2
rs622476583T/CADAMTS9-AS21.099.9 × 10−20.889.5 × 10−3
rs1406471813T/CCOL8A11.644.8 × 10−20.980.91
rs100339004C/TCFI0.980.670.930.13
rs623583615G/TC91.060.820.675.4 × 10−2
rs1140922505G/APRLR/SPEF20.611.4 × 10−20.950.80
rs1165037766G/AC2/CFB/SKIV2L0.751.6 × 10−30.950.61
rs9430806T/CVEGFA0.940.200.960.37
rs78034547C/TPILRB/PILRA1.000.991.212.5 × 10−3
rs11427C/TKMT2E/SRPK21.010.831.050.36
rs790370408T/GTNFRSF10A0.950.280.960.42
rs715070149GC/GTRPM30.990.860.902.8 × 10−2
rs107811829G/TMIR6130/RORB0.882.0 × 10−20.903.6 × 10−2
rs16263409G/ATGFBR10.920.240.940.32
rs27404889A/CABCA10.990.811.040.52
rs1235725710G/AARHGAP211.070.261.100.11
rs375084610T/CARMS2/HTRA11.441.3 × 10−111.225.9 × 10−5
rs313814112C/ARDH5/CD631.184.4 × 10−20.960.58
rs6194127412G/AACAD101.140.501.000.98
rs956469213C/TB3GALTL0.831.6 × 10−30.940.24
rs6198513614T/CRAD51B1.176.6 × 10−30.980.76
rs204308515T/CLIPC1.141.2 × 10−20.990.88
rs581708216C/CACETP0.906.8 × 10−21.080.22
rs7280234216C/ACTRB2/CTRB10.796.3 × 10−20.890.32
rs1108005517C/ATMEM97/VTN1.113.3 × 10−21.080.13
rs656559717C/TNPLOC4/TSPAN101.040.481.010.79
rs6753802619C/TCNN20.893.2 × 10−20.909.4 × 10−2
rs223019919C/GC30.861.6 × 10−20.970.64
rs42935819T/CAPOE0.950.561.030.73
rs14245000620TTTTC/TMMP90.761.7 × 10−30.768.9 × 10−4
rs20145990120T/TAC20orf851.050.610.900.38
rs575422722T/CSYN3/TIMP30.900.190.753.3 × 10−4
rs813566522C/TSLC16A80.990.861.020.79
  • Model was adjusted for baseline age, education, smoking status, and study eye’s baseline AMD severity score.

  • a The locus name is a label of the region using the nearest gene(s), but does not necessarily state the responsible gene.