Table 7 Harrell’s concordance index (c-index) and Brier scores (BrSs) for different prediction models evaluated in all eyes
Modelac-indexbAREDSAREDS2
BrSc (4 yr)BrS (10 yr)iBrSd (up to 4 yr)iBrS (up to 10 yr)c-indexBrS (4 yr)iBrS (up to 4 yr)
A0.620.0790.1520.0270.0790.610.1810.074
B0.750.0730.1310.0260.0710.630.1790.074
C0.880.0560.0830.0220.0510.720.1610.068
D0.890.0550.0820.0220.0500.730.1550.067
E0.890.0550.0800.0220.0500.730.1540.067
  • These prediction models were established using AREDS data and evaluated on both AREDS and AREDS2.

  • a Predictors for each model are given in Table 6.

  • b In AREDS, the c-index values were computed based on bootstrapped samples (average over 50 times).

  • c In AREDS, the Brier scores were computed based on fivefold cross-validation.

  • d iBrS: integrated Brier score.