Table 5 Multivariable robust Cox model result on progression to advanced AMD
AREDSAREDS2Test for differencea
HR (95% CI)P ValueHR (95% CI)P ValueP Value
Variable
 Age (yr)1.05 (1.03, 1.06)6.4 × 10−101.06 (1.05, 1.07)2.8 × 10−280.14
 Smoking
  NeverReferenceReference
  Former1.14 (0.98, 1.33)0.061.18 (1.02, 1.37)0.030.75
  Current1.98 (1.51, 2.58)5.7 × 10−71.30 (0.92, 1.81)0.130.05
 Education
  ≤High schoolReferenceReference
  >High school0.87 (0.75, 1.01)0.060.92 (0.78, 1.07)0.270.65
 Baseline study eye AMD severity score1.85 (1.78, 1.92)4.3 × 10−2261.90 (1.74, 2.07)8.7 × 10−480.61
GRSb1.34 (1.26, 1.42)1.6 × 10−221.11 (1.05, 1.18)2.1 × 10−41.0 × 10−5
  • a For each model coefficient estimate [i.e., log(HR)], a Wald test was performed to test whether the coefficient estimates differ between AREDS and AREDS2.

  • b For 0.1 unit increase in GRS.