Table 3 Nonsynonymous substitutions in MLH1 and PMS1
StrainAmino acid position in MLH1
240271a333678703761
S288cSLEDPD
SK1RPKNLG
YJM523SLEDPD
YJM320SPENLG
Amino acid position in PMS1
41112384392400401416b513564768818
S288cNIFETATYAKR
SK1STVESATCEGTFAKK
YJM523NIVVSSTCEGTYVRK
YJM320NIVVSSTCEGTYVRK
  • All substitutions that result in amino acid changes are shown relative to the S288c strain. S288c, SK1, and YJM320 are compatible for the MLH1–PMS1 genotype; YJM523 is incompatible.

  • a Proline residue at MLH1-271 partially suppresses the cMLH1–kPMS1 incompatibility (Demogines et al. 2008b).

  • b Compared to S288c, SK1, YJM523, and YJM320b strains/isolates contain a four amino acid insertion (CEGT) after T416 in PMS1.