Table 1 Parameters and baseline values
SymbolParameteraBaseline Valueb
λDensity-independent recruitment rate6
γDensity-dependent recruitment rate1
Embedded ImageInitial frequency of resistance0
Embedded ImageInitial release frequenciesEmbedded Image
Embedded ImageProbability of cleavage0.995
Embedded ImageProbability of non-HR0.02
Embedded ImageProbability nuclease gene lost during homingEmbedded Image
Embedded ImageProbability effector lost during homing (I)Embedded Image
Embedded ImageProbability nuclease and effector lost during homing (I)Embedded Image
Embedded ImageProbability that non-HR of w produces functional r allele (II)0
Embedded ImageDominance coefficient for target site disruption0.5/0.03
Embedded ImageCost of target site disruption0/1
Embedded ImageDominance coefficient for nuclease expression0.5
Embedded ImageCost of nuclease expression0.05
Embedded ImageDominance coefficient for effector expression0.5
Embedded ImageCost of effector expression0.1
Embedded ImageDominance coefficient for refractoriness1
Embedded ImageHomozygous degree of refractoriness1
Embedded ImageProbability of spontaneous mutation of wild type allele (II)Embedded Image
Embedded ImageProbability of spontaneous mutation of nuclease allele (II)Embedded Image
Embedded ImageProbability of spontaneous mutation of effector allele (II)Embedded Image
  • a I, Model I only; II, Model II only.

  • b Given as Model I/Model II if different.