Table 2 Summary of neighbor associations with mutations in malignant melanoma
DirectionEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
AEmbedded ImageC0.0167−10.0101(−1, +1)0.0078(−2, +1, +2)
AEmbedded ImageG0.0135−10.0118(−1, +1)0.0051(−1, +1, +2)
AEmbedded ImageT0.0110−10.0039(−2, +1)0.0033(−2, −1, +1)
CEmbedded ImageA0.0319−10.0102(−1, +1)
CEmbedded ImageG0.0264+10.0035(−1, +1)0.0041(−2, −1, +1)
CEmbedded ImageT0.0788−10.0130(−1, +1)0.0006(−2, −1, +1)
GEmbedded ImageA0.0918+10.0090(−1, +1)0.0009(−1, +1, +2)
GEmbedded ImageC0.0254−10.0028(−2, +1)0.0043(−1, +1, +2)
GEmbedded ImageT0.0242+10.0078(+1, +2)0.0052(−1, +1, +2)
TEmbedded ImageA0.0123+10.0042(+1, +2)0.0044(−1, +1, +2)
TEmbedded ImageC0.0135+10.0244(−1, +1)0.0057(−1, +1, +2)
TEmbedded ImageG0.0137+10.0118(−1, +1)0.0074(−2, +1, +2)
  • Embedded Image is the maximum RE for order # and Embedded Image the corresponding position(s). All point mutations had at least one significant test after correcting for 15 tests (see Table S1 in File S1) using the Holm-Šidäk procedure. Nonsignificant results are indicated by “—.”