Table 5 Top genes from the COPDGene exome sequencing study using five different methods
GeneeScoreeRLRTeLRTSKATSKAT-oPositionChrSetSize
Height**
 ANKRD39Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image97,521,89622
 ATP5DEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image1,243,764193
 BHMT2Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image78,379,54352
 CDC16Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image115,028,428131
 DOLPP1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image131,848,18692
 EVX2Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image176,948,41622
 FAM204AEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image120,095,908101
 FASLGEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image172,628,47713
 IFNGR1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image137,521,19563
 KRTAP13-1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image31,768,732214
 MN1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image28,194,819225
 NDRG4Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image58,529,726162
 PLD6Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image17,107,768172
 RAPH1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image20,432,454023
 TTC1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image15,947,390353
 ZER1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image131,512,38295
 ZNF513Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image27,601,13627
PackYears*
 SIN3AEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image75,693,827155
BMI*
 ADAMTS70.10Embedded ImageEmbedded Image0.10Embedded Image79,073,8761521
 ADRA2AEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image112,838,638102
 APOLD1Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image12,909,721124
 HEPHEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image65,434,4852311
 SNAPC5Embedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image66,788,877153
  • Genes that pass Bonferroni corrected genome-wide significance level of 3 × 10−6 are in boldface font. Position is the base pair position in the middle of the gene. Chr, chromosome of the test region; SetSize, the number of SNPs in the test region. ** P < 3 × 10−6, * P < 10−4.