Table 1 List of published DMS studies assessing mutant growth rates in accordance with our statistical model, arranged by number of time points sampled
ReferenceNo. of time pointsNo. of mutantsTotal no. of sequence reads (millions)Reproducibility (if reported)Summary of reference
Hietpas et al. (2013)6 or 756830Embedded Image for full replicatesBeneficial single substitutions in Hsp90 of yeast under altered environments
Jiang et al. (2013)6 or 756834Embedded Image for full replicatesInteraction of expression and single substitutions on DFE of yeast Hsp90
Puchta et al. (2016)5–7≈60,000545.7Embedded ImageNetwork of epistatic interactions in yeast small nucleolar RNA
Roscoe et al. (2013)61,53021Embedded Image for full replicatesFunctional biophysics of single substitutions in ubiquitin of yeast
Hietpas et al. (2011)3 or 756826Embedded Image for full replicatesDFE of single substitutions for a short region of Hsp90 in yeast
Bank et al. (2015)51,01521.6Credibility intervals (figure 6B)DFE of epistatic substitutions in Hsp90 of yeast
Wu et al. (2013)3>400>0.002NACompensatory single substitutions for neuraminidase mutant of influenza
Li et al. (2016)265,537685.5Embedded Image mean across 15 pairs of biological replicatesFitness landscape of a transfer RNA gene in yeast
Jiang et al. (2015)247520.5Embedded Image for full replicatesBiophysics of single substitutions in influenza neuraminidase with antiviral
Roscoe and Bolon (2014)21,61730Embedded Image for full replicatesBiophysics of single ubiquitin substitutions on E1 activity and yeast fitness
Melnikov et al. (2014)24,99333.2Embedded Image for full replicatesBiophysics of single substitutions in APH(3′)II in Escherichia coli with antibiotics
Kim et al. (2013)229,70890.2NABiophysics of single substitutions in yeast Deg1 protein degradation signal
Melamed et al. (2013)2110,745186.5NABiophysics of single and multiple substitutions in Pab1 RRM of yeast
Klesmith et al. (2015)29,2195.8Reproducibility plotBiophysics of levoglucosan consumption rate in E. coli