Table 4 The reproductive defects of din-1S mutants correlate with the frequency of hyperplasia in the somatic gonad and postdauer germline cell division abormalities
GenotypeaNo. of proximal somatic gonadal cells in dauerbDauer-dependent reproductive defectsc (%)
Bag of worms (n)Sterility (n)Gonad arms containing polyploid germ cell nucleid (n)
daf-2(e1370)6 ± 04.2 (165)0 (165)0 (100)
din-1S(rr94); daf-2(e1370)25.4 ± 19.218.2 (165)33.9 (165)23.9 (92)
daf-7(e1372)6 ± 00 (86)0 (86)0 (56)
din-1S(rr94); daf-7(e1372)87.6 ± 10.190 (80)7.5 (80)5.9 (102)
  • n, sample size.

  • a Full genotype includes qIs56.

  • b Mean ± SD; n ≥ 20.

  • c Results for animals that spent 24 hr in dauer at 25°.

  • d Gonad arms containing polyploid germ cell nuclei were scored in animals ∼24 hr after the L4/adult molt.