Table 1 Candidate gene expression levels predicting behavior
Mouse HS open field LOD scores (additive model)
ChrTraitQTL C.I. (Mb)eQTLPhQTL posGene P-valueNEO leo.nb scoreModel P-valueMarkerLatencyTotal activityTime in centerMarker
2Time in center zone trial 245.5–51.9SFRP42@4260.04NANArs2709114rs13481716
2Time in center zone trial 245.5–51.9STK17A2@4260.004NANArs1181601rs6253368
3Minimum total movement25.1–27RSPH93@2770.030.8235.48E-06rs37784934.77.8UT_17_45.56
3Minimum total movement25.1–27C1orf107/DIEXF3@2770.0030.3680.804rs7549523rs3684501
8Total velocity average23.9–26.6RABGGTB8@194.00.05NANArs7555627rs3656403
10Total velocity average4.3–6.8ADAM1010@1010.030.440.396rs2242321rs13480265
10Total velocity average4.3–6.8APBA210@1010.010.04210.0719rs76803217.7rs3717846
10Total velocity trial 114.4–17.4LOC77035210@185.00.0020.9430.687rs14806174.5rs13476065
10Total movement average14.4–17.4LOC77035210@185.00.00021.070.956rs14806174.5rs13476065
10Minimum total movement14.4–17.4LOC77035210@182.00.0030.8740.925rs14806174.5rs13476065
10Total movement trial 27.6–15.0LOC77035210@64.00.00120.7470.878rs14806174.5rs13476065
10Maximum total movement14.4–17.4LOC77035210@185.00.00031.130.985rs14806174.5rs13476065
10Total velocity trial 14.3–6.8APBA210@99.00.0040.9770.131rs76803217.7rs3717846
10Total velocity trial 14.3–6.8ADAM1010@99.00.040.5150.37rs2242321rs13480265
10Total movement trial 14.3–6.8LOC77035210@99.00.0080.8150.852rs76803214.5rs13476065
10Total movement average4.3–6.8APBA210@99.00.02−0.9660.0002rs76803217.7rs3717846
13Total velocity trial 21.5–4.1GABRB213@32.00.0014NANArs43026295.15.1rs6225242
17Total velocity average1–2.5SLC31A117@10.004NANArs786978rs3690581
17Total velocity trial 11–2.5SLC31A117@10.003NANArs786978rs3690581
  • Chromosome (Chr) and QTL confidence interval are given for the trait that each eQTL significantly correlated with. The phenotypic QTL position (PhQTL pos) is also given in centimorgans. The P-value of the correlation, after Bonferroni correction, is also provided (Gene P-value). The causality modeling scores are also indicated for each gene, as are the WTCCC P-values for each gene region. The association of each gene with the mouse HS cross is also given, with the LOD scores of the gene location for each of the three different open field tests provided.