Table 1 LOH events detected by whole genome sequencing of mutation accumulation lines
Diploid homozygous genotypepol2-M644G RNH201pol2-M644G rnh201Δ
Number of isolates sequenced87
Total generations elapsed72006300
Total mutation count436912
LOH count14111
Mean LOH rate (per Mbp per generation)38140
Standard deviation (per Mbp per generation)3341
Fold difference in rate3.7
Welch’s t-test P-value0.00019
  • All rates are lower bound estimates per mega base pairs (Mbp) per generation. Lower bound LOH rates are estimated for each isolate thus: (homozygous mutation count)/(mutation count)/(generations elapsed).