Table 1 LOH events detected by whole genome sequencing of mutation accumulation lines

Diploid homozygous genotype	pol2-M644G RNH201	pol2-M644G rnh201Δ
Number of isolates sequenced	8	7
Total generations elapsed	7200	6300
Total mutation count	436	912
LOH count	14	111
Mean LOH rate (per Mbp per generation)	38	140
Standard deviation (per Mbp per generation)	33	41
Fold difference in rate	3.7
Welch’s t-test P-value	0.00019

All rates are lower bound estimates per mega base pairs (Mbp) per generation. Lower bound LOH rates are estimated for each isolate thus: (homozygous mutation count)/(mutation count)/(generations elapsed).