Table 1 Suppression of para^bss1/+ bang-sensitivity (BS) by mutant Rab proteins

Drosophila gene	Human ortholog(s)^{^a}		*57C10 BS (%)*	*57C10 n*	*GAL4U BS (%)*	*GAL4U n*	P- value^{^b}	Stock no.^{^c}
Rab3	Rab3a, 3b,3c, 3d	CA	100	45	100	35	1	9764
Rab3	Rab3a, 3b,3c, 3d	DN	93	41	94	36	1	9766
Rab5	Rab5a, 5b, 5c, 17	CA	60	45	96	28	0.0004*	9773
Rab5	Rab5a, 5b, 5c, 17	DN	85	124	84	107	1	9771
Rab8	Rab8a, 8b, 13, 12	CA	97	32	86	28	0.174	9781
Rab8	Rab8a, 8b, 13, 12	DN	81	101	92	97	0.038*	9780
Rab9	Rab9a, 9b	CA	78	99	90	99	0.033*	9785
Rab9	Rab9a, 9b	DN	74	66	92	71	0.011*	23642
Rab23	Rab23	CA	98	95	98	46	1	9806
Rab23	Rab23	DN	97	36	100	41	1	9804
Rab27	Rab27a, 27b	CA	88	69	100	17	0.347	23266
Rab27	Rab27a, 27b	DN	92	25	100	47	0.117	23267
Rab30	Rab30	CA	65	110	78	115	0.027*	9814
Rab30	Rab30	DN	75	99	89	84	0.011*	9813
Rab32	Rab32	CA	95	44	95	22	1	23280
Rab32	Rab32	DN	76	87	98	45	0.001*	23281
Rab35	Rab35	CA	91	150	94	180	0.206	9818
Rab35	Rab35	DN	92	112	100	66	0.027*	9819

Summary of Rab GTPases used in this study and their effects on suppression of para^bss1/+ bang sensitivity. The nine Rab GTPases used in the screen were chosen because of evidence indicating colocalization with CSP, a synaptic vesicle marker (Jin et al. 2012).
↵a Human orthologs were determined from Gillingham et al. (2014).
↵b P-values obtained from a Fisher’s exact test comparing the bang sensitivity of the para^bss1/+; GAL4U/UAS-Rab (control) compared to the para^bss1/+; R57C10/UAS-Rab (experimental) genotype.
↵c Bloomington Stock Center number for the UAS-Rab transgene used in the experiment (Zhang et al., 2006).