Table 1 Suppression of parabss1/+ bang-sensitivity (BS) by mutant Rab proteins
Drosophila geneHuman ortholog(s)a57C10 BS (%)57C10 nGAL4U BS (%)GAL4U nP- valuebStock no.c
Rab3Rab3a, 3b,3c, 3dCA100451003519764
DN9341943619766
Rab5Rab5a, 5b, 5c, 17CA604596280.0004*9773
DN851248410719771
Rab8Rab8a, 8b, 13, 12CA973286280.1749781
DN8110192970.038*9780
Rab9Rab9a, 9bCA789990990.033*9785
DN746692710.011*23642
Rab23Rab23CA9895984619806
DN97361004119804
Rab27Rab27a, 27bCA8869100170.34723266
DN9225100470.11723267
Rab30Rab30CA65110781150.027*9814
DN759989840.011*9813
Rab32Rab32CA95449522123280
DN768798450.001*23281
Rab35Rab35CA91150941800.2069818
DN92112100660.027*9819
  • Summary of Rab GTPases used in this study and their effects on suppression of parabss1/+ bang sensitivity. The nine Rab GTPases used in the screen were chosen because of evidence indicating colocalization with CSP, a synaptic vesicle marker (Jin et al. 2012).

  • a Human orthologs were determined from Gillingham et al. (2014).

  • b P-values obtained from a Fisher’s exact test comparing the bang sensitivity of the parabss1/+; GAL4U/UAS-Rab (control) compared to the parabss1/+; R57C10/UAS-Rab (experimental) genotype.

  • c Bloomington Stock Center number for the UAS-Rab transgene used in the experiment (Zhang et al., 2006).