Table 4 Trinucleotide repeat tract dynamics in microcolony time courses
GenotypeType of eventNumber of eventsMedian size of event (range in number of repeats)
MSH3(CTG)aExpansion383 (1–14)
Contraction303 (1–8)
Final TNR tract length33 (27–46)
msh3Δ(CTG)bExpansion103 (1–6)
Contraction182 (1–7)
Final TNR tract length30 (29–32)
  • a Ninety-six total time courses were initiated: 32 time courses were completed to at least day 12; of these,13 exhibited TNR tract dynamics, 2 exhibited a stable tract length, 15 exhibited no tract amplification, and 2 were uninterpretable due to high background.

  • b One-hundred and five total time courses were initiated: 37 time course were completed to at least day 10; of these, 14 exhibited TNR tract dynamics, 9 exhibited a stable tract length, and 14 exhibited no tract amplification.