Table 1 Results for GWAS with genotypic model
KORA sampleTwinsUK sample
SNPMetabolite (ratio)ChrPositionGeneAFP-value genotypicAFP-value genotypicReplicated
rs7552404C12/C10175,908,534ACADM0.3001.69 × 10−720.3141.89 × 10−29*
rs7601356C9/PC.ae.C30.02210,764,902ACADL0.6321.24 × 10−700.6496.86 × 10−28*
rs715Gly/Gln2211,251,300CPS10.6874.28 × 10−690.7031.12 × 10−48*
rs8396C7.DC/C104159,850,267ETFDH0.7075.98 × 10−260.6783.14 × 10−17*
rs2046813PC.ae.C42.5/PC.ae.C44.54186,006,153ACSL10.6886.29 × 10−170.6871.18 × 10−3*
rs273913C5/PC.ae.C34.15131,689,055SLC22A40.4051.60 × 10−160.3514.19 × 10−2
rs3798719PC.aa.C42.5/PC.aa.C40.3611,144,811ELOVL20.2485.01 × 10−320.2344.01 × 10−4*
rs12356193C01061,083,359SLC16A90.1662.18 × 10−270.1611.20 × 10−7*
rs603424C16.1/C1410102,065,469PKD2L10.8013.70 × 10−180.8181.99 × 10−2
rs174547PC.aa.C36.3/PC.aa.C36.41161,327,359FADS10.7012.29 × 10−2080.6492.09 × 10−76*
rs2066938C3/C412119,644,998ACADS0.2701.73 × 10−1590.2572.17 × 10−67*
rs4902242PC.aa.C28.1/PC.ae.C40.21463,299,842SYNE20.8492.00 × 10−350.8724.78 × 10−15*
rs1077989PC.ae.C32.1/PC.ae.C34.11467,045,575PLEKHH10.4636.80 × 10−420.4724.05 × 10−18*
rs4814176SM..OH..C24.1/SM..OH..C22.12012,907,398SPTLC30.3642.69 × 10−310.4169.69 × 10−9*
rs6970485lysoPC.a.C28.0/PC.aa.C26.0711,752,704THSD7A0.3541.21 × 10−47
rs1894832Ser/Trp756,144,740LOC3894930.5081.98 × 10−120.5114.02 × 10−3
rs2657879His/Gln1255,151,605GLS20.2072.89 × 10−140.1861.90 × 10−6*
rs7200543PC.aa.C36.2/PC.aa.C38.31615,037,471NTAN10.3127.45 × 10−160.2771.66 × 10−6*
rs1466448SM.C18.1/SM.C16.1198,195,519CERS40.2227.01 × 10−160.1943.90 × 10−10*
rs5746636xLeu/Pro2217,276,301DGCR60.2362.98 × 10−200.2732.40 × 10−3*
  • This table reports the results for 20 loci that had a significant P-value for the genotypic model in KORA F4 (P < 2.19 × 10−12). Sixteen loci were replicated in the TwinsUK data (P < 0.0025) and are marked with an asterisk in the last column. Per locus, the SNP and metabolite or metabolite ratio with the lowest P-value in KORA is given. The table is divided into two parts: the upper part reports loci that were already found in the previously published GWAS on the same data (Illig et al. 2010); the lower part shows novel loci. AF, allele frequency of the effect allele; Chr, chromosome.