Table 4 Results for GWAS with additive model
KORA sampleTwinsUK samplegene info
SNPMetabolite (ratio)ChrPositionA/BAFP-value additiveAFP-value additiveGeneGene pos.
rs7552404C12/C10175,908,534G/A0.3001.84 × 10−730.3141.25 × 10−30ACADMDownstream*
3223rs477992Ser/Orn1120,059,099A/G0.7025.75 × 10−130.6588.11 × 10−9PHGDHinGene*
rs2286963C9/PC.ae.C34.02210,768,295G/T0.6291.68 × 10−600.6512.14 × 10−31ACADLinGene*
rs715Gly/Gln2211,251,300C/T0.6871.00 × 10−610.7034.37 × 10−49CPS1Upstream*
rs8396C7.DC/C104159,850,267C/T0.7074.54 × 10−270.6782.72 × 10−17ETFDHinGene*
rs2046813PC.ae.C42.5/PC.ae.C44.54186,006,153C/T0.6887.11 × 10−180.6872.71 × 10−4ACSL1Upstream*
rs270613C5/Val5131,668,482A/G0.6068.03 × 10−170.6472.57 × 10−3SLC22A4inGene
rs3798719PC.aa.C42.5/PC.aa.C40.3611,144,811T/C0.2486.78 × 10−330.2341.32 × 10−4ELOVL2inGene*
rs12356193C01061,083,359G/A0.1662.42 × 10−280.1611.70 × 10−8SLC16A9inGene*
rs603424C16.1/C1410102,065,469A/G0.8011.42 × 10−180.8185.36 × 10−3PKD2L1inGene
rs174547PC.aa.C36.3/PC.aa.C36.41161,327,359C/T0.7015.98 × 10−2090.6491.00 × 10−74FADS1inGene*
rs2066938C3/C412119,644,998G/A0.2707.49 × 10−1490.2571.59 × 10−63ACADSDownstream*
rs4902242PC.aa.C28.1/PC.ae.C40.21463,299,842C/T0.8493.77 × 10−360.8721.30 × 10−15SYNE2Upstream*
rs1077989PC.ae.C32.1/PC.ae.C34.11467,045,575C/A0.4631.99 × 10−420.4725.18 × 10−18PLEKHH1Downstream*
rs4814176SM..OH..C24.1/SM..OH..C22.12012,907,398T/C0.3642.00 × 10−320.4167.67 × 10−8SPTLC3Downstream*
rs1374804Ser/Gly3127,391,188A/G0.6381.70 × 10−120.6191.03 × 10−1ALDH1L1Upstream
rs6970485lysoPC.a.C28.0/PC.aa.C26.0711,752,704C/T0.3544.66 × 10−41THSD7AinGene
rs1894832Ser/Trp756,144,740C/T0.5084.02 × 10−130.5118.92 × 10−4LOC389493Downstream*
rs2657879His/Gln1255,151,605G/A0.2074.44 × 10−150.1861.57 × 10−6GLS2inGene*
rs7200543PC.aa.C36.2/PC.aa.C38.31615,037,471G/A0.3121.40 × 10−160.2772.55 × 10−7NTAN1Downstream*
rs1466448SM.C18.1/SM.C16.1198,195,519C/A0.2221.31 × 10−160.1945.12 × 10−11CERS4inGene*
rs5746636xLeu/Pro2217,276,301T/G0.2362.64 × 10−210.2738.94 × 10−4DGCR6inGene*
  • This table reports the results for 22 loci that had a significant P-value in KORA (p < 2.19 × 10−12) for the additive model. Eighteen loci were replicated in the TwinsUK data (P < 0.0023). Per locus, the SNP and metabolite or metabolite ratio with the lowest P-value in KORA is given. The table is divided into two parts: the upper part consists of loci that were already found in Illig et al. (2010); the lower part shows new loci. SNPs that were replicated are marked by an asterisk. AF, allele frequency of the effect allele; B, effect allele; Chr, chromosome.