Table 3 Results for SNPs reported in previous GWAS on the same data (Illig et al. 2010)
Best SNP reported in Illig et al. (2010)Best metabolite/ratio reported in Illig et al. (2010)ChrPositionA/BP-value genotypicP-value additiveAF (B)GeneBest SNP of genotypic screeningBest metabolite/ratio of genotypic screeningDist. (in bp)
rs211718C12/C10175,879,263T/C1.9 × 10−721.6 × 10−730.3ACADMrs7552404C12/C1029,271
rs541503Orn/Ser1120,009,820C/T3.9 × 10−115.0 × 10−110.63PHGDH
rs2286963C9/C10.22210,768,295G/T1.3 × 10−655.8 × 10−600.63ACADLrs7601356C9/PC.ae.C30.03,393
rs2216405Gly/PC.ae.C38.22211,325,139G/A5.6 × 10−313.3 × 10−310.19CPS1rs715Gly/Gln73,839
rs8396C14.1.OH/C104159,850,267C/T3.4 × 10−233.9 × 10−240.71ETFDHrs8396C7.DC/C100
rs2046813PC.ae.C44.5/PC.ae.C42.54186,006,153C/T8.3 × 10−179.8 × 10−180.69ACSL1rs2046813PC.ae.C42.5/PC.ae.C44.50
rs272889Val/C55131,693,277A/G4.4 × 10−155.1 × 10−160.62SLC22A4rs273913C5/PC.ae.C34.14,222
rs9393903PC.aa.C40.3/PC.aa.C42.5611,150,895A/G6.9 × 10−321.0 × 10−320.75ELOVL2rs3798719PC.aa.C42.5/PC.aa.C40.36,084
rs7094971C01061,119,570G/A3.7 × 10−213.2 × 10−220.15SLC16A9rs12356193C036,211
rs603424C14/C16.110102,065,469A/G5.4 × 10−181.6 × 10−180.8SCDrs603424C16.1/C140
rs174547PC.aa.C36.3/PC.aa.C36.41161,327,359C/T6.3 × 10−2091.5 × 10−2090.7FADS1rs174547PC.aa.C36.3/PC.aa.C36.40
rs2014355C3/C412119,659,907C/T8.9 × 10−1211.7 × 10−1100.73ACADSrs2066938C3/C414,909
rs11158519PC.ae.C38.1/PC.aa.C28.11463,434,338A/G4.4 × 10−68.0 × 10−70.86SYNE2rs4902242PC.aa.C28.1/PC.ae.C40.2134,496
rs7156144PC.ae.C32.1/PC.ae.C34.11467,049,466A/G2.1 × 10−314.8 × 10−320.59PLEKHH1rs1077989PC.ae.C32.1/PC.ae.C34.13,891
rs168622SM..OH..C24.1/SM.C16.02012,914,089T/G3.5 × 10−213.1 × 10−220.36SPTLC3rs4814176SM..OH..C24.1/SM..OH..C22.16,691
  • This table summarizes the results for the 15 previously reported SNPs and corresponding traits (Illig et al. 2010). Results are given for the additive and genotypic models at these SNPs in our analyses. Moreover, per locus, the best SNP and metabolite or metabolite ratio identified with the genotypic screening is given along with the distance to the SNP reported in Illig et al. (2010). One locus was not found with the genotypic screening. A, other allele; AF, allele frequency of the effect allele; B, effect allele; Chr, chromosome.