Table 1 Evolutionary conservation of homologous recombination proteins and examples of related human diseases
Functional classS. cerevisiaeH. sapiensAssociated disease(s)References
End resectionMre11-Rad50-Xrs2MRE11-RAD50-NBS1Nijmegen breakage syndrome; AT-like disorder(Varon et al., 1998)
Sae2CtIP
Exo1EXO1Colorectal cancer(Yang et al., 2014)
Dna2-Sgs1-Top3-Rmi1DNA2-BLM-TOP3-RMI1-RMI2Bloom syndrome(Kaneko and Kondo, 2004)
AdaptorsRad953BP1, MDC1Breast cancer(Bartkova et al., 2007; Rapakko et al., 2007)
-BRCA1Breast cancer(Petrucelli et al., 2010)
Checkpoint signalingTel1ATMAtaxia-telangiectasia(Gatti et al., 2001)
Mec1-Ddc2ATR-ATRIPSeckel syndrome(O'Driscoll et al., 2003)
Rad53CHK2
Rad24-RFCRAD17-RFC
Ddc1-Mec3-Rad17RAD9-HUS1-RAD1
Dpb11TOPBP1Breast cancer(Karppinen et al., 2006)
Single-stranded DNA bindingRfa1-Rfa2-Rfa3RPA1-RPA2-RPA3
Single-strand annealingRad52RAD52
Rad59-
MediatorsRad52-
-BRCA2-PALB2Breast cancer(Petrucelli et al., 2010)
Strand exchangeRad51RAD51Breast cancer(Nissar et al., 2014; Sun et al., 2011)
Rad54RAD54A, RAD54B
Rdh54-
Rad51 paralogsRad55-Rad57RAD51B-RAD51C-RAD51D-XRCC2-XRCC3Breast cancer(Silva et al., 2010; Vuorela et al., 2011)
Psy3-Csm2-Shu1-Shu2RAD51D-XRCC2-SWS1
Anti-recombinasesSrs2FBH1, PARI
Mph1FANCMFanconi Anemia(Meetei et al., 2005)
-RTEL1Hoyeraal-Hreidarsson syndrome(Ballew et al., 2013)
Resolvases and nucleasesMus81-Mms4MUS81-EME1
Slx1-Slx4SLX1-SLX4Fanconi Anemia(Crossan et al., 2011; Kim et al., 2011; Stoepker et al., 2011)
Yen1GEN1
Rad1-Rad10XPF-ERCC1Xeroderma pigmentosum(Gregg et al., 2011)