Table 4 Genetic interactions between hotspots
PeakID Interacting hotspotMapping regimeaTotal linkagesEnrichment summaryChr.Candidate gene
1Peak12B, E52Ribi clusterIII
2Peak12R12RPs, translation, ribosomeX
3Peak13 (HAP1)B, E62iESR, response to heatIOAF1
4Peak13 (HAP1)E, R66RPs, translation, ribosomeVTSC11/DOT6
5Peak15 (PHO84)B, E, R118iESRVURA3
6Peak15 (PHO84)R21RPsV
7Peak17 (MKT1)R22Intracellular mRNA localizationXIII
8Peak17 (MKT1)B, E41Mitochondrial RPs, mitochondrial translationXV
9Peak18E, R61RPs, translation, ribosomeVTSC11/DOT6
10Peak19B, E, R50mitochondrial RPsX1D Peak25
11Peak2 (AMN1)E17RPs, translation, ribosomeVIICYS4
12Peak24 (RNA15)B24Electron transport chain, aerobic respirationIVNDE2
13Peak30 (PRE6)E10Asparagine metabolism, response to nitrogen starvationXIV
14Peak31 (FAA2)B22RiBi clusterVII
15Peak31 (FAA2)R21RiBi clusterVIICIR1
16Peak31 (FAA2)E12iESRXIPHD1
17Peak32B, E, R93Mitochondrial RPsXIVMKT1
18Peak36B, E25MatingIV
19Peak4 (MAT-ALPHA1)B, E, R24MatingIV
20Peak4 (MAT-ALPHA1)E34RPs, translation, ribosomeVIII
21Peak4 (MAT-ALPHA1)B, E48iESRXII
22Peak7 (URA3)B, R55RPs, translation, ribosomeXIII
23Peak12B16Cell cycleXIIHAP1
24Peak13 (HAP1)B, E17Cell cycleIX
  • iESR, induced ESR genes; rESR, repressed ESR genes; RiBi: ribosome biogenesis genes in the ESR.

  • a Mapping regime: basal abundance (B), ethanol abundance (E), and ethanol response (R); the mapping was performed using the combined crosses (see Materials and Methods).