Table 3 eQTL hotspots
PeakMappingaCrossbTotal linkagesEnrichment summaryChr.Candidate gene
1B, EBoth53Fatty acid metabolismIOAF1 (Litvin et al. 2009)
2B, E, RBoth98Cell divisionIIAMN1 (Yvert et al. 2003)
3B, EYS85
4B, E, RBoth37Mating, HMRIIIMAT-ALPHA1
5BMS28Electron transport, iron-sulfur cluster, metal bindingIVRGT2
6B, EMS32Y′ elementsIV
7BBoth81Fatty acid oxidation, cell wallVURA3
8B, E, RYS285iESRVTSC11/DOT6
9B, EMS124VIIVPS73
10B, RMS74Methionine/sulfate metabolismVIICYS4 (Kim and Fay 2007)
11B, E, RYS126Mitochondrial RPsVIICIR1
12B, E, RBoth152VIII
13B, E, RBoth376Sterol biosynthesis, respirationXIIHAP1 (Brem et al. 2002)
14B, EYS47Dubious ORFs/Y′ elementsXII
15B, E, RBoth152Vacuole, arginine metabolism, phosphate metabolismXIIIPHO84 (Perlstein et al. 2007)
16BMS24XIIIPSE1
17B, E, RBoth1264Mitochondrion, mitochondrial RPsXIVMKT1 (Lee et al. 2009)
18B, RBoth47XV
19BBoth35XV
20BMS28XV
21BYS33Phosphorous metabolismXVIFUM1
22EYS26IVNDE2
23EYS35IV
24EBoth33mRNA processingVIIRNA15
25EYS30X
26E, RMS60iESR, trehaloseXIIPHD1
27EMS35vacuoleXIII
28EMS25XIV
29EMS36XV
30EBoth25XVPRE6
31E, RBoth79VFAA2
32RBoth48Ribi cluster, nucleolusVIIISBP1, RPL8A
33RYS20X
34RMS22IV
35RMS39Ribosome biogenesisVII
36EBoth27III
37EYS28II
  • iESR, induced ESR genes; rESR, repressed ESR genes; RiBi: ribosome biogenesis genes in the ESR. References are provided for candidate genes observed in other QTL studies.

  • a Mapping regime: basal abundance (B), ethanol abundance (E), and ethanol response (R).

  • b Cross where hotspot was observed: S288c × M22 (MS), S288c × YPS163 (YS), or both.