Table 2 Genes negatively regulated by JAK/STAT
Probe Set IDGene NameFC oe/wtFC lof/wtFunctionHuman HomologSB SitesConserved SBSReported Target
1640035_atFbp2−57.72.9lipid metabolismFBP2
1638338_a_atFbp1−22.22.7protein transporterFBP1
1635689_atLcp2−21.11.9structural constituent of larval cuticleLCP2
1623675_atObp99b−20.71.7odorant binding protein
1626830_atLcp1−83.5structural constituent of larval cuticleLCP1
1626429_atLsp1−72.7oxygen transporterLSP1
1628699_atLsp1−72.1oxygen transporterLSP1
1638108_atSgs8−6.713.9structural molecule activity, puparial adhesion4/993Yes
1634409_atCG31775−61.7unknown
1641070_atCG9021−5.91.5protein binding4/629
1626088_atCG2177−5.53.1metal ion transporterSLC39A9Upa
1626910_atCG15282−5.22.7unknown2/705
1634997_atSgs5−515.5puparial adhesion
1632529_attinc−4.61.5eye photoreceptor cell development2/278
1629106_atCG2233−4.52unknown
1627946_atCG12068−42.1visual perceptionHSD17B6
1635549_atTotA−3.82.7regulation of translation3/146
1633607_atCG2444−3.71.8unknown
1630238_atLcp4−3.51.7unknown4/596
1635548_s_atCG15281−3.52.1unknown
1631701_a_atCG8502−3.41.6structural constituent of larval cuticleATP1B2
1637552_s_atCG32423−31.7mRNA processingRBMS12/102
1627219_atnAcR64B−31.5cation transportCHRNA4
1630593_atNLaz−2.91.9lipid transportAPODDowna
1641634_atLsp2−2.82.1transport
1630635_s_atCG7720−2.82cation transporter activitySLC5A83/511Downa
1631059_atPkc98E−2.71.8protein serine/threonine kinase activityPRKCE2/183
1634525_atCG7738−2.63.6protein binding2/735
1638789_atfau−2.61.8protein bindingFAU
1638314_atCG12418−2.61.7unknown
1625880_atCG17618−2.61.4maintenance of cell polarity
1629229_a_atsrp−2.41.9transcription factorGATA62/542
1632121_a_atCG6416−2.41.6mesoderm development3/479
1624211_atCG9005−2.41.4unknownFAM214
1634012_atCG5002−2.31.9anion transportSLC26A113/254Yes
1625236_s_atProsap−2.31.4protein binding3/354YesDowna
1634447_atCG31140−2.21.4diacylglycerol kinase activityDGKH
1636835_atCG16700−2.21.3amino acid transportSLC36A4Upa
1632431_s_atAnce−2.12.1proteolysis,peptidyl-dipeptidase A activityACEDowna
1628005_atCG31666/chinmo−2.11.4zinc finger transcription factorBTBD102/219Upa,b
1633048_atCG8193−2.11.4transport
1638899_s_atCG15312−2.11.3unknownCNTN22/520
1639079_atAdgf-D−21.6adenosine deaminase activity, cell proliferationCECR12/910Yes
1624686_a_atdnc−21.43′,5′-cyclic-AMP phosphodiesterasePDE4D4/985Yes
1634552_atTepIV−21.3endopeptidase inhibitor activity4/785
1630095_a_atDrl-2−1.91.8transmembrane receptor protein tyrosine kinaseRYK4/764
1625967_s_atl(3)10615−1.91.5unknown
1629889_s_atregucalcin−1.91.4calcium-mediated signaling2/829Yes
1631554_atCG11473−1.91.4unknown
1624363_atCG15201−1.82.7unknownRGN
1627242_atl(2)efl−1.82.7protein foldingCRYAB
1626842_a_atl(3)82Fd−1.81.6cell wall catabolismNCOA72/427Yes
1638820_atCG12870−1.81.6apoptosis2/236
1628757_atGlut1−1.76glucose transporter activitySLC2A1
1626113_atCG4080−1.72.3ubiquitin cycle, zinc fingerC3HC42/454
1636313_atCG4914−1.72.1transcription factorTMPRSS11BDowna
1639320_a_atDdc−1.71.9catecholamine metabolismDDC
1631215_atCG32132−1.71.8unknown
1636103_a_atnocturnin−1.71.7nucleic acid bindingCCRN4L2/322
1625462_s_atCG31221−1.71.4lipoprotein receptor activityBRCA22/98
1639826_atCG32662−1.71.4unknownGOLGA6L102/64
1640729_s_atnrv3−1.71.4potassium ion transport2/620
1633592_a_atCREG−1.62.2transcriptional repressor activityCREG12/310
1628632_atPaip2−1.61.4negative regulation of translationPAIP22/275
1627151_atCG4612−1.61.3mRNA bindingPABPN1
1626417_atCht3−1.41.5chitinase activityCHIA3/621
1626272_s_atCG3066−1.41.3serine carboxypeptidase
1636122_atSocs16D−1.41.3signal transductionSOCS7
  • FC, fold change; wt, wild type; oe, upd overexpression; lof, hopM4; SB Sites, STAT92E binding sites, the numbers refer to the number of STAT92E binding sites in the number of base pairs of DNA sequence; Conserved SBS, STAT92E binding sites found in other Drosophila species, indicated by “Yes.” Up, positive regulation by JAK/STAT; Down, negative regulation by JAK/STAT.

  • a Flaherty et al. (2009).

  • b Terry et al. (2006).