Table 3 Summary of characterization of APC2 proteins and their ability to rescue destruction complex function in APC2 null and APC2 APC1 double-null embryos
GenotypeCortical localization in S2 cells and embryosCo-IP with Arm from S2 cellsRescue of APC2 null defects in Wnt signalingRescue of APC double-null defects in Wnt signaling in the MZ+ progenyRescue of APC double-null defects in Wnt signaling in the MZ progeny
Wild type++NANANA
APC2-FL++++++
APC2R3–R5SA++++++
APC2R3–R5SD++++++
APC2R3–R5ExR++++++
APC2R1–R5SA++++
APC2R1–R5SD++++
APC2R1–R5ExR+++/−
APC2-Δ20RΔB+++/−
APC2-Δ15RΔ20RΔB+++/−
  • NA, not applicable.