TABLE 4

Summary of simulation result

At least one significant?aTop-ranking causal?bDistant noncausal found?c
ModelAdditiveorxorAdditiveorxorAdditiveorxor
Latent North–South variable1.001.000.860.700.490.000.230.431.00
Two causal loci1.001.000.940.960.800.860.250.760.81
  • a Fraction of results with at least one significant SNP (at a Bonferroni-corrected threshold of 0.05) and that were used for subsequent analysis.

  • b Fraction of results in which the top-ranking association was a causal polymorphism (the causal polymorphism in the case of a latent variable).

  • c Fraction of results in which a SNP more strongly associated with the phenotype than a casual polymorphism (the causal polymorphism in the case of a latent variable) was >50 kb away from the nearest causal polymorphism.