TABLE 1

Model specification

Latent variableCausative polymorphismNoncausal markerPhenotypeGenotype frequency
0000a
0010b
010βCc
011βCd
100βLe
101βLf
110βC + βL + βLCg
111βC + βL + βLCh
  • The model is defined as a “genotype” of three binary factors, L, C, and N. Every combination of these factors perfectly describes a phenotype P and occurs with a frequency indicated by a, … , h. Table 2 defines some useful parameterizations.