TABLE 1

Summary of the role of Gyc-89Da and Gyc-89Db and the neurons in which they are expressed during the hypoxia escape response and changes in ARS behavior responses to hypoxia and hyperoxia

Gyc-89Da−/− mutantGyc-89Db−/− mutant
DaGAL4 UASDaDaGAL4 UASDbDbGAL4 UASDaDbGAL4 UASDbDaGAL4 UASDaDaGAL4 UASDbDbGAL4 UASDaDbGAL4 UASDb
Hypoxia escape response rescued
YesYesYesYesYesYesYesYes
ARS behavior rescued
21%-15%YesYesNoNoNDNDNDND
21%-19%NDNDNDNDNoNoYesYes
21%-24%NDNDNDNDNoNoYesYes
  • The hypoxia escape response was rescued at all oxygen concentrations when either subunit was expressed in either Gyc-89Da or Gyc-89Db neurons in both mutants. By contrast the area restricted search (ARS) behavior was rescued by either subunit but only if it was expressed in the correct neurons for that mutation. ND, not determined.