TABLE 1

Sixteen in silico loci chosen as high priority loci controlling serum cytokine concentrations in inbred murine strains in response to systemic LPS challenge

Locus no.ChrLocus boundaries (Mb)PhenotypeMethodAssociated SNP (Mb)P-value(s)Published QTL
1123–28IL-1βPlink264278313.90E-101
IL-6Plink26445071, 26459079, 269026864.90E-07
KCEMMA24076131, 24330584, 24967418, 24967436, 264146825.6E-3; 6.8E-3
21145.5–147KCPlink1456830601.20E-072
TNFαEMMA146725976.40E-03
3268–70KCPlink694385371.20E-073
4280.5–82.5KCPlink80841547, 80883004, 81138233, 81560669, 81615533, 81617733, 81628234, 81658448, 81659050, 81678285, 81704287, 81718343, 81789194, 82079297, 82079512, 82084458, 82117829, 82122611, 82126777, 82143108, 821436351.20E-073
52106.5–109IL-1 βEMMA107315924, 107357384, 107398624, 107412136, 107959779, 108073860, 1081856295.40E-033
6578–82IL-6Plink79316768, 79549852, 802655454.90E-074
KCEMMA80712378, 814266496.80E-03
7659.5–64TNFαPlink615609745.20E-06
IL-6Plink615609744.40E-08
KCEMMA62063800, 612405546.9E-3; 7.1E-3
8782.5–106TNFαPlink8853602, 93333165.20E-065
IL-6Plink8853602, 93333164.40E-08
IL-1βPlink95953303.90E-10
97115–118IL-1βPlink1166018093.90E-105
IL-6Plink1169164074.90E-07
10821–23.5IL-6EMMA22106945, 22224999, 22185337, 22262697, 22277352, 221150308E-4; 1.2E-3; 1.3E-3; 1.5E-3; 1.4E-3
KCPlink22416276, 225368361.20E-07
11978–81.5TNFαPlink79331943, 806618995.2E-6; 9.1E-6
IL-1βPlink801492403.90E-10
IL-6Plink806618994.40E-08
121156.2–60.2IL-6EMMA592501608.00E-046–8
KCEMMA572873785.60E-03
131348–58IL-6EMMA5173293, 5273676, 5461529, 5675544,1.40E-039, 10
141427–30IL-1βPlink283727053.90E-10
IL-6Plink288001014.90E-07
151491.3–93IL-1βPlink91942359, 923107813.90E-10
KCPlink921454641.20E-07
161531.5–33TNFαPlink325061735.20E-0611, 12
IL-1βPlink325414543.90E-10
IL-6Plink32504050, 325061734.9E-7; 4.4E-8
  • 1, Ses1.1 locus; bacterial load in the spleen in response to iv S. enteritidis in (C57BL/6J × 129S6) F2 intercross and 129.B6-Ses1.1 congenic mice (Caron et al. 2002, 2005); 2, Susceptibility to iv S. typhimurium in (C57BL/6J × MOLF/Ei) F2 mice (Sebastiani et al. 1998); 3, Lptl1 locus; pulmonary TNFα levels following aerosolized LPS challenge in (C57BL/6J × DBA/2J) F2 and RI mice (Cook et al. 2004b); 4, Hpi2 locus; hepatic PMN infiltration in response to systemic LPS in BXA RI mice (Matesic et al. 2000); 5, Ses2 locus; bacterial load in the spleen in response to iv S. enteritidis in (C57BL/6J × 129S6) F2 intercross and 129.B6-Ses2 congenic mice (Caron et al. 2002, 2005); 6, Lppl1 and Lptl2 loci; pulmonary PMN recruitment and TNFα levels following aerosolized LPS challenge in (C57BL/6J × DBA/2J) F2 and RI mice (Cook et al. 2004b); 7, Mol4 locus; splenocyte proliferation in vitro following systemic LPS challenge in AXB and BXA RI strains (Matesic et al. 1999); 8, Susceptibility to iv S. typhimurium in (C57BL/6J × MOLF/Ei) F2 mice (Sebastiani et al. 1998); 9, Hpi1 locus; hepatic PMN infiltration in response to systemic LPS in BXA RI mice (Matesic et al. 2000); 10, Mol3 locus; splenocyte proliferation in vitro following systemic LPS challenge in AXB and BXA RI strains (Matesic et al. 1999); 11, Ses3 locus; bacterial load in the spleen in response to iv S. enteritidis in (C57BL/6J × 129S6) F2 intercross and 129.B6-Ses3 congenic mice (Caron et al. 2002, 2005); 12, Susceptibility to iv S. typhimurium in (C57BL/6J × MOLF/Ei) F2 mice (Sebastiani et al. 1998).