TABLE 4

SNPs associating with immune gene induction phenotypes

Female inductionMale induction
Functional classGeneLocationChangeDefDptAMtkPGRP-SATsf1DefDptAMtkPGRP-SATsf1
Signalpole holeExon0.9970.8200.5060.2300.1700.5510.5180.9540.976<0.001***
Transduction3.0
pole holeExon0.9970.8200.8870.2300.1700.3680.1970.9540.1440.056*
1.8
TRAF2Intergenic0.023*0.8700.8130.1610.2470.5510.922NA0.9760.806
6.7
TRAF3ExonNA<0.001***NA0.228NA0.382<0.001***0.954NANA
7.14.8
Secretedupd2Exon<0.001***0.8201.0000.2480.1700.5510.9430.6810.9760.042*
0.37.9
Iron metabolismTsf1Exon<0.001***NA0.017*0.228NANANANANANA
4.51.6
HematopoesisPvf1ExonA → TNA0.381NANANA0.5510.518NANANA
Pvf1Exon0.9970.8200.9920.1610.075*0.5510.546NA0.9760.806
1.7
Serine proteaseSer7Intergenic<0.001***NA<0.001***0.228NANANANANANA
4.61.2
Ser7Exon0.2610.8200.046*0.2720.075*0.5510.197NA0.9760.806
14.34.5
Combined inductionEffect of Sex × SNP interaction on induction
Functional classGeneLocationChangeDefDptAMtkPGRP-SATsf1DefDptAMtkPGRP-SATsf1
Signalpole holeExon0.5820.6820.4250.4810.2770.9230.620NA0.7590.539
Transduction
pole holeExon0.5990.6450.6200.4120.3870.9060.3180.7600.6940.592
TRAF2Intergenic0.5940.8740.4250.5490.9120.7880.832NA0.6570.763
TRAF3Exon0.448<0.001***0.6200.515NANANANANANA
5.9
Secretedupd2Exon0.1490.8740.6200.5490.3870.7880.8320.7600.6570.488
Iron metabolismTsf1Exon0.1190.899<0.001***0.5150.273NANANANANA
1.7
HematopoesisPvf1ExonA → T0.8490.450NA0.5150.657NA0.620NA<0.001***NA
0.3
Pvf1Exon0.6910.4500.6200.5150.9120.9060.832NA0.6570.539
Serine proteaseSer7Intergenic<0.001***0.902<0.001***0.515<0.001***NANANANANA
0.20.50.0
Ser7Exon0.5900.4500.1040.5490.908NA0.741NA0.7500.539
  • q-values shown for SNPs that associate with at least one induction phenotype at an FDR ≤10% (q ≤ 0.1) are shown; 79 of the 88 SNPs tested showed no association with any induction phenotype. Percentage of phenotypic variance explained by association is shown for each test with q < 0.1 (below q-value). Change, amino acid change associated with SNP, where applicable. *q < 0.1, ***q < 0.001.