TABLE 2

Mutational parameters used in simulations

ModelλE[s]βE[h]No. lociSegregatingEpistatic
I0.050.201.000.20840660390
II0.100.100.330.342,2401,7751,054
III0.500.040.250.4114,00010,1435,504
  • Rate of mutation per gamete and generation (λ), average homozygous deleterious effect (E[s]), shape parameter for the gamma distribution of homozygous effects (β), and average degree of dominance (E[h]) for new mutations assuming h uniformly distributed between 0 and exp(−7.5s) are shown. The numbers of simulated loci, those segregating at the MSD balance (base population), and those where the corresponding epistatic pair is also segregating at the MSD balance are also given.